Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications

Methods in Enzymology
Shigeo Ohta

Abstract

Molecular hydrogen (H2) was believed to be inert and nonfunctional in mammalian cells. We overturned this concept by demonstrating that H2 reacts with highly reactive oxidants such as hydroxyl radical ((•)OH) and peroxynitrite (ONOO(-)) inside cells. H2 has several advantages exhibiting marked effects for medical applications: it is mild enough neither to disturb metabolic redox reactions nor to affect signaling by reactive oxygen species. Therefore, it should have no or little adverse effects. H2 can be monitored with an H2-specific electrode or by gas chromatography. H2 rapidly diffuses into tissues and cells to exhibit efficient effects. Thus, we proposed the potential of H2 for preventive and therapeutic applications. There are several methods to ingest or consume H2: inhaling H2 gas, drinking H2-dissolved water (H2-water), injecting H2-dissolved saline (H2-saline), taking an H2 bath, or dropping H2-saline onto the eyes. Recent publications revealed that, in addition to the direct neutralization of highly reactive oxidants, H2 indirectly reduces oxidative stress by regulating the expression of various genes. Moreover, by regulating gene expression, H2 functions as an anti-inflammatory, antiallergic, and antiapoptotic molecu...Continue Reading

Citations

Dec 23, 2015·BioMed Research International·Fan WuYi Lin
Nov 12, 2016·Frontiers in Pharmacology·Yaxing ZhangTinghuai Wang
Feb 22, 2017·Medical Gas Research·Lei Huang
Jun 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tyler W LeBaronJan Slezak
Oct 22, 2019·Radiation Research·Mengya LiuXiujun Qin
Apr 11, 2019·Canadian Journal of Physiology and Pharmacology·Tyler W LeBaronJan Slezak
Nov 19, 2019·Acta Biochimica Et Biophysica Sinica·Geru TaoShucun Qin
Jun 20, 2020·PloS One·Motoaki SanoEiji Kobayashi
Jun 24, 2017·The Journal of Trauma and Acute Care Surgery·Tadashi MatsuokaJunichi Sasaki
Feb 10, 2018·Expert Opinion on Investigational Drugs·Chun-Lan ChenWei-Jie Guan
Feb 3, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yasuhiro TerasakiIkuroh Ohsawa
Nov 14, 2015·Journal of Clinical Biochemistry and Nutrition·Tomoko NakanoFumitaka Kikkawa
Jan 17, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Ayca Ergan SahinDamla Karabıyık
Mar 16, 2021·Chemical Research in Toxicology·Kuang-Den ChenHo-Chang Kuo
Apr 4, 2021·International Journal of Molecular Sciences·Shin-Ichi HiranoFumitake Satoh
Apr 9, 2021·Molecular and Cellular Biochemistry·Mengna ZhengNan Huang
Mar 27, 2021·Current Opinion in Critical Care·Aurora Magliocca, Michael Fries
Aug 9, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiongge HuAnwen Shao
Aug 28, 2021·International Journal of Molecular Sciences·Shin-Ichi HiranoFumitake Satoh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.