Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status

Free Radical Biology & Medicine
Jonatas E NogueiraLuiz G S Branco

Abstract

Physical exercise induces inflammatory and oxidative markers production in the skeletal muscle and this process is under the control of both endogenous and exogenous modulators. Recently, molecular hydrogen (H2) has been described as a therapeutic gas able to reduced oxidative stress in a number of conditions. However, nothing is known about its putative role in the inflammatory and oxidative status during a session of acute physical exercise in sedentary rats. Therefore, we tested the hypothesis that H2 attenuates both inflammation and oxidative stress induced by acute physical exercise. Rats ran at 80% of their maximum running velocity on a closed treadmill inhaling either the H2 gas (2% H2, 21% O2, balanced with N2) or the control gas (0% H2, 21% O2, balanced with N2) and were euthanized immediately or 3 h after exercise. We assessed plasma levels of inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6] and oxidative markers [superoxide dismutase (SOD), thiobarbituric acid reactive species (TBARS) and nitrite/nitrate (NOx)]. In addition, we evaluated the phosphorylation status of intracellular signaling proteins [glycogen synthase kinase type 3 (GSK3α/β) and the cAMP responsive element bindin...Continue Reading

Citations

Apr 11, 2019·Canadian Journal of Physiology and Pharmacology·Tyler W LeBaronJan Slezak
Aug 20, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Alessandra C Toledo-ArrudaMilton A Martins
Feb 6, 2020·Oxidative Medicine and Cellular Longevity·Takuji KawamuraIsao Muraoka
Dec 29, 2020·Canadian Journal of Physiology and Pharmacology·Jonatas E NogueiraLuiz G S Branco
Sep 24, 2020·Current Pharmaceutical Design·Sergej M Ostojic
Nov 14, 2020·Current Pharmaceutical Design·Jonatas E Nogueira, Luiz G S Branco

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