Molecular identification and antifungal susceptibility testing of clinical isolates of the Candida rugosa species complex and proposal of the new species Candida neorugosa.

Journal of Clinical Microbiology
Katihuska ParedesJosep Guarro

Abstract

Candida rugosa is a poorly known fungal species occasionally involved in human infections. A molecular analysis of the sequences of the D1/D2 domains and the internal transcribed spacer (ITS) region of the ribosomal genes of 24 clinical isolates phenotypically identified as C. rugosa demonstrated that only 10 (41.6%) isolates belonged to that species. The other isolates were identified as Candida pararugosa (41.6%) and Candida pseudorugosa (8.3%). The remaining two isolates, from human and equine infections, respectively, were clearly different from the others and represent a new species proposed here as Candida neorugosa. The closest species by D1/D2 sequences was the type strain of C. rugosa, with only 92.3% similarity. C. neorugosa can also be differentiated from all other species of the C. rugosa complex by phenotypic features. The eight antifungal drugs tested showed high in vitro activity against the 24 isolates included in the study.

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Citations

Oct 29, 2013·Fungal Genetics and Biology : FG & B·Ana Carolina Barbosa PadovanArnaldo Lopes Colombo
Jun 28, 2016·Diagnostic Microbiology and Infectious Disease·Marta SanchisJavier Capilla
Jun 17, 2016·Journal of Clinical Microbiology·David W Warnock
Oct 28, 2019·Current Topics in Medicinal Chemistry·Laura Nunes SilvaAndré Luis Souza Dos Santos
Sep 1, 2012·Current Fungal Infection Reports·Mary E Brandt, Shawn R Lockhart
Jun 11, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·David A DargatzBeth Harris
Apr 11, 2018·Medical Mycology·Chunyan MingYingqian Kang
Mar 23, 2021·Case Reports in Infectious Diseases·Gabriella PiattiAlberto Ballestrero

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