Molecular identification of GHS-R and GPR38 in Suncus murinus

Peptides
Airi SuzukiTakafumi Sakai

Abstract

We previously identified ghrelin and motilin genes in Suncus murinus (suncus), and also revealed that motilin induces phase III-like strong contractions in the suncus stomach in vivo, as observed in humans and dogs. Moreover, repeated migrating motor complexes were found in the gastrointestinal tract of suncus at regular 120-min intervals. We therefore proposed suncus as a small laboratory animal model for the study of gastrointestinal motility. In the present study, we identified growth hormone secretagogue receptor (GHS-R) and motilin receptor (GPR38) genes in the suncus. We also examined their tissue distribution throughout the body. The amino acids of suncus GHS-R and GPR38 showed high homology with those of other mammals and shared 42% amino acid identity. RT-PCR showed that both the receptors were expressed in the hypothalamus, medulla oblongata, pituitary gland and the nodose ganglion in the central nervous system. In addition, GHS-R mRNA expressions were detected throughout the stomach and intestine, whereas GPR38 was expressed in the gastric muscle layer, lower intestine, lungs, heart, and pituitary gland. These results suggest that ghrelin and motilin affect gut motility and energy metabolism via specific receptors ex...Continue Reading

References

May 1, 1973·Canadian Journal of Biochemistry·J C BrownJ R Dryburgh
Jan 1, 1974·Canadian Journal of Biochemistry·H Schubert, J C Brown
Jan 1, 1996·Peptides·P De ClercqT L Peeters
Aug 31, 2000·Biochemical and Biophysical Research Communications·Y DateM Nakazato
Oct 12, 2000·Biochemical and Biophysical Research Communications·Y MasudaK Kangawa
Apr 27, 2001·Endocrine·R G SmithA Howard
Sep 8, 2001·The Journal of Biological Chemistry·H KaiyaK Kangawa
May 22, 2002·Journal of Cardiovascular Pharmacology·Hiroyuki OkumuraKenji Kangawa
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Sharmilee GnanapavanMárta Korbonits
Jun 11, 2002·Biochemical and Biophysical Research Communications·Leen ThielemansTheo L Peeters
Aug 24, 2002·Endocrinology·Hiroyuki KaiyaKenji Kangawa
Sep 3, 2003·Biochemical and Biophysical Research Communications·Mark S DuxburyEdward E Whang
Jan 12, 2005·The Journal of Endocrinology·Giuseppina MaccarinelliDaniela Cocchi
Dec 3, 2005·The Journal of Clinical Investigation·Jeffrey M ZigmanJoel K Elmquist
Dec 31, 2005·Pharmacological Reviews·Anthony P DavenportKeniji Kangawa
Sep 18, 2007·Regulatory Peptides·Hiroyuki OhshiroKatsuomi Ichikawa
Jan 29, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hiroyuki KaiyaSuraj Unniappan
Apr 25, 2008·General and Comparative Endocrinology·Ichiro YamamotoMinoru Tanaka
Jul 10, 2008·Biochemical and Biophysical Research Communications·Kaori FukumotoNoboru Murakami
Sep 3, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J ZhengT Takahashi
Nov 15, 2008·World Journal of Gastroenterology : WJG·Koji YakabiShingo Kato
Aug 22, 2009·Journal of Molecular Endocrinology·Jing HeYa-Ping Zhang
Oct 21, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T NakamuraT Kitazawa
Dec 1, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Simona Perboni, Akio Inui
Apr 22, 2010·Experimental Biology and Medicine·Ignacio A Gómez de SeguraEnrique De Miguel
May 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rumi TanakaMineko Fujimiya
Aug 6, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Satoshi SakaharaTakafumi Sakai
May 6, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Diego Perez-TilvePaul Pfluger
Oct 28, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A MondalT Sakai
Mar 3, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anupom MondalTakafumi Sakai

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Citations

Sep 24, 2015·Nature Reviews. Gastroenterology & Hepatology·Gareth J Sanger, John B Furness
Sep 23, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Wen-jing CaiYang Qiao
Apr 12, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Amrita DudaniTakafumi Sakai
May 11, 2015·Biochemical and Biophysical Research Communications·Chayon GoswamiIchiro Sakata
May 18, 2016·General and Comparative Endocrinology·Auvijit Saha ApuIchiro Sakata
Apr 8, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Seungwoo KangJiang-Hong Ye
Feb 23, 2019·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Taichi HoritaIchiro Sakata
Jun 4, 2019·Frontiers in Endocrinology·Takio Kitazawa, Hiroyuki Kaiya
Jan 25, 2019·Nature Reviews. Endocrinology·Eveline DelooseJan Tack

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