Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1.

Blood
J M MouldsL Miller

Abstract

Complement receptor 1 (CR1) has been implicated in rosetting of uninfected red blood cells to Plasmodium falciparum-infected cells, and rosette formation is associated with severe malaria. The Knops blood group (KN) is located on CR1 and some of these antigens, ie, McCoy (McC) and Swain-Langley (Sl(a)), show marked frequency differences between Caucasians and Africans. Thus, defining the molecular basis of these antigens may provide new insight into the mechanisms of P falciparum malaria. Monoclonal antibody epitope mapping and serologic inhibition studies using CR1 deletion constructs localized McC and Sl(a) to long homologous repeat D of CR1. Direct DNA sequencing of selected donors identified several single nucleotide polymorphisms in exon 29 coding for complement control protein modules 24 and 25. Two of these appeared to be blood group specific: McC associated with K1590E and Sl(a) with R1601G. These associations were confirmed by inhibition studies using allele-specific mutants. A sequence-specific oligonucleotide probe hybridization assay was developed to genotype several African populations and perform family inheritance studies. Concordance between the 1590 mutation and McC was 94%; that between Sl(a) and 1601 was 88%....Continue Reading

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Citations

Nov 12, 2005·Immunogenetics·Craig A McLureRoger L Dawkins
Nov 15, 2003·Lancet·Marina NorisUNKNOWN International Registry of Recurrent and Familial HUS/TTP
Aug 14, 2001·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J P Cartron, Y Colin
Nov 8, 2002·Trends in Molecular Medicine·Malgorzata Krych-GoldbergJohn P Atkinson
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Mar 16, 2002·Transfusion·J M MouldsJ J Moulds
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Apr 29, 2015·Pathogens and Global Health·Rebecca TetteyDaniel Dodoo

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