Molecular identity of cardiac mitochondrial chloride intracellular channel proteins

Mitochondrion
Devasena PonnalaguHarpreet Singh

Abstract

Emerging evidences demonstrate significance of chloride channels in cardiac function and cardioprotection from ischemia-reperfusion (IR) injury. Unlike mitochondrial potassium channels sensitive to calcium (BKCa) and ATP (KATP), molecular identity of majority of cardiac mitochondrial chloride channels located at the inner membrane is not known. In this study, we report the presence of unique dimorphic chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4, CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to adult cardiac mitochondria. We found that CLIC4 is enriched in the outer mitochondrial membrane, whereas CLIC5 is present in the inner mitochondrial membrane. Also, CLIC5 plays a direct role in regulating mitochondrial reactive oxygen species (ROS) generation. Our study highlights that CLIC5 is localized to the cardiac mitochondria and directly modulates mitochondrial function.

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Citations

Oct 11, 2016·Journal of cardiovascular ultrasound·Andrew KohutHarpreet Singh
Dec 6, 2017·Veterinary Research·Jiri VolfIvan Rychlik
Nov 16, 2018·British Journal of Pharmacology·Luigi LeanzaIldiko Szabo
Dec 5, 2018·American Journal of Respiratory Cell and Molecular Biology·Dilip ShahVineet Bhandari
Nov 3, 2016·American Journal of Physiology. Renal Physiology·Mahtab TavasoliBarbara J Ballermann
Aug 10, 2016·PloS One·Amanda LeeShubha Gururaja Rao
Oct 5, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dilip ShahVineet Bhandari
Jan 25, 2020·Journal of Cell Science·Matthew ZajacYamuna Krishnan
Mar 3, 2020·Frontiers in Physiology·Shubha Gururaja RaoHarpreet Singh
Jul 25, 2018·Current Protocols in Pharmacology·Shubha Gururaja RaoHarpreet Singh
Apr 25, 2020·Frontiers in Physiology·Devasena Ponnalagu, Harpreet Singh
Aug 23, 2020·Antioxidants·Kalina Szteyn, Harpreet Singh
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paul W HotzLuca Mendler
Jan 10, 2021·Redox Biology·Ildiko SzaboLucia Biasutto
Jan 11, 2021·Biochimica Et Biophysica Acta. Bioenergetics·Shane Austin, Karin Nowikovsky
Feb 15, 2020·British Journal of Pharmacology·Umberto De MarchiJaime Santo-Domingo
Jun 3, 2021·International Journal of Molecular Sciences·Stine F PedersenLuis A Pardo
Jul 20, 2021·Molecular Medicine Reports·Hui WangBiguang Tuo
Aug 28, 2021·Antioxidants·Priyanka KarekarShubha Gururaja Rao
Sep 23, 2021·American Journal of Physiology. Cell Physiology·Harpreet Singh

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