Molecular imaging in tracking tumor stem-like cells.

Journal of Biomedicine & Biotechnology
Tian XiaHong Zhang

Abstract

Cancer remains a major public health problem in many countries. It was found to contain a subset of cancer stem cells (CSCs) that are capable of proliferation and self-renewal, and differentiation into various types of cancer cells. CSCs often display characteristics of chemotherapy resistance and radiotherapy resistance. Numerous putative biomarkers of CSCs are currently identified including CD133, CD44, CD24, ALDH (aldehyde dehydrogenase), and ABCG2. Interestingly, no single marker is exclusively expressed by CSCs. Thus, the various combinations of different biomarkers will be possible to identify CSCs, and considerable work is being done to recognize new ones. In order to demonstrate the mechanisms of resistance and response to therapy and predict the outcome as well as prognosis, the ways to track and identify CSCs will be extremely important. The technologies of molecular imaging will reveal mechanisms of cancer progression and provide visual targets for novel therapeutics. Limited studies were investigated on the detection of various types of CSCs by molecular imaging. Although the tracking of circulating CSCs is still hampered by technological challenges, personalized diagnosis and therapies of cancers are expected to be...Continue Reading

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Citations

Jan 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Simone GaedickeGabriele Niedermann
May 31, 2014·Tissue Engineering. Part B, Reviews·Yoon JeongKwan Hyi Lee
May 27, 2014·International Journal of Molecular Sciences·Nicola Pacini, Fabio Borziani
Dec 19, 2015·Journal of Cellular Physiology·Riccardo Di FioreRenza Vento
May 23, 2014·International Journal of Radiation Biology·Claudia PeitzschIna Kurth
Mar 10, 2016·International Journal of Molecular Sciences·Nicola Pacini, Fabio Borziani
Oct 22, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Silvia ValtortaRosa Maria Moresco

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Methods Mentioned

BETA
fluorescence-activated cell sorter
FACS
xenograft
xenografts
surgical resection
imaging technology
imaging techniques
imaging technique
fluorescence imaging

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