Molecular Imaging of Breast Cancer: Role of RGD Peptides

Mini Reviews in Medicinal Chemistry
Rubel ChakravartyAshutosh Dash

Abstract

Breast cancer is the leading cause of cancer deaths among women of all ages worldwide. With advances in molecular imaging procedures, it has been possible to detect breast cancer in its early stage, determine the extent of the disease to administer appropriate therapeutic protocol and also monitor the effects of treatment. By accurately characterizing the tumor properties and biological processes involved, molecular imaging can play a crucial role in minimizing the morbidity and mortality associated with breast cancer. The integrin αvβ3 plays an important role in breast cancer angiogenesis and is expressed on tumor endothelial cells as well as on some tumor cells. It is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic acid (RGD) tripeptide sequence and therefore RGD peptides can preferentially bind to integrin αvβ3. In this context, targeting tumor vasculature or tumor cells by RGD-based probes is a promising strategy for molecular imaging of breast cancer. Using RGD-based probes, several preclinical studies have employed different imaging modalities such as positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), ultraso...Continue Reading

Citations

Feb 3, 2016·Journal of Labelled Compounds & Radiopharmaceuticals·Rubel ChakravartyAshutosh Dash
Aug 3, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Rubel ChakravartyAshutosh Dash
Jul 20, 2018·Chemistry : a European Journal·Scott K ShawBradley D Smith
Apr 18, 2018·Nuclear Medicine and Molecular Imaging·Akanksha JainAshutosh Dash
Sep 17, 2019·Life Sciences·Sajjad Ahmadpour, Seyed Jalal Hosseinimehr
May 1, 2021·International Journal of Molecular Sciences·Vrinda GoteDhananjay Pal
May 1, 2021·Pharmaceutics·Alex N FrickensteinLacey R McNally
Apr 28, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jiang WuXiaoyuan Chen
Oct 7, 2016·Molecular Pharmaceutics·Rubel ChakravartyAshutosh Dash
Mar 7, 2019·Chemical Reviews·Heather D AgnewJames R Heath
Sep 11, 2021·Frontiers in Chemistry·Carsten HöltkeAnne Helfen

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