Molecular imaging of drug-eluting coronary stents: method development, optimization and selected applications

Journal of Mass Spectrometry : JMS
Jiun-Tang HuangGyorgy Vas

Abstract

A molecular imaging application was developed to characterize the drug distribution on CYPHER® and NEVO™ Drug-eluting Stents using MALDI Qq-ToF analytical methodology. The coating matrix, laser energy, laser frequency, spatial resolution (related to rastering speed) and mass spectrometer parameters were optimized to analyze drug distribution in both durable and biodegradable polymer matrices. The developed method was extended to generate data from stents explanted from porcine coronary arteries. Due to the method's intrinsic specificity, it offers a significant advantage over other techniques in that it allows low-level detection of the target molecule without biological interferences from the blood or tissue. The method is also capable of detecting drug-related degradation products both from the finished stent product and from explanted stents.

References

Jun 11, 1999·Journal of the American Society of Nephrology : JASN·J F GummertR E Morris
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Jan 16, 2004·The New England Journal of Medicine·Gregg W StoneUNKNOWN TAXUS-IV Investigators
Aug 13, 2005·Journal of the American Society for Mass Spectrometry·John C JurchenJonathan V Sweedler
Aug 2, 2006·Biomaterials·Xintong WangLay Poh Tan
Nov 28, 2006·The Journal of Physical Chemistry. a·R KnochenmussM Faderl
May 19, 2007·Journal of Mass Spectrometry : JMS·K Olaf BoernsenUwe Christians
Jan 19, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anna BeluKlaus Wormuth
Feb 26, 2008·Journal of the American Society for Mass Spectrometry·Audrey M Schaiberger, Jason A Moss
May 17, 2008·Pediatric Transplantation·Guido FillerUwe Christians
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marika KamberiDebra Feder
Apr 13, 2010·Biomaterials·Tingfei XiShengping Zhong
Nov 27, 2010·Journal of the American College of Cardiology·George D DangasRoxana Mehran
Dec 4, 2010·Journal of Pharmaceutical and Biomedical Analysis·Xiaodong MaRoger Laham

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Citations

Feb 5, 2016·Methods : a Companion to Methods in Enzymology·Christopher A MitchellMalcolm R Clench
Apr 24, 2015·Journal of the American Society for Mass Spectrometry·Jeffrey M SpragginsRichard M Caprioli
Dec 14, 2019·Rapid Communications in Mass Spectrometry : RCM·Paola RizzarelliGraziella Valenti

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