Molecular imaging of postprandial metabolism

Journal of Applied Physiology
Vera B Schrauwen-Hinderling, André C Carpentier

Abstract

Disordered postprandial metabolism of energy substrates is one of the main defining features of prediabetes and contributes to the development of several chronic diseases associated with obesity, such as type 2 diabetes and cardiovascular diseases. Postprandial energy metabolism has been studied using classical isotopic tracer approaches that are limited by poor access to splanchnic metabolism and highly dynamic and complex exchanges of energy substrates involving multiple organs and systems. Advances in noninvasive molecular imaging modalities, such as PET and MRI/magnetic resonance spectroscopy (MRS), have recently allowed important advances in our understanding of postprandial energy metabolism in humans. The present review describes some of these recent advances, with particular focus on glucose and fatty acid metabolism in the postprandial state, and discusses current gaps in knowledge and new perspectives of application of PET and MRI/MRS for the investigation and treatment of human metabolic diseases.

References

Jun 1, 1992·The Journal of Clinical Investigation·P NuutilaU Wegelius
Dec 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S Patlak, R G Blasberg
Jul 1, 1995·Journal of Molecular and Cellular Cardiology·M J KnuutiP Nuutila
Aug 1, 1995·The Journal of Clinical Investigation·P NuutilaV A Koivisto
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·P PeltoniemiP Nuutila
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Kirsi A VirtanenPirjo Nuutila
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Patricia IozzoPirjo Nuutila
Aug 14, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michael D JensenJames A Levine
Dec 1, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·K HällstenP Nuutila
Nov 3, 2005·Physics in Medicine and Biology·Steven R MeikleRichard B Banati
Apr 6, 2006·Annals of Internal Medicine·Jonathan M McGavockUNKNOWN American College of Physicians and the American Physiological Society
Jun 23, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Xiuli CiAndré C Carpentier
Aug 1, 2007·Diabetes·Susanne B VotrubaMichael D Jensen
Nov 10, 2007·Diabetes·Susanne LercheAlbert Gjedde
Jan 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Hugo W A M de JongAdriaan A Lammertsma
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Apr 10, 2009·The New England Journal of Medicine·Kirsi A VirtanenPirjo Nuutila
May 7, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Cristina ZingarettiSaverio Cinti
Jan 21, 2010·Physiological Reviews·Luc Tappy, Kim-Anne Lê
Nov 26, 2010·American Journal of Physiology. Endocrinology and Metabolism·Sébastien M LabbéAndré C Carpentier
Jan 29, 2011·Diabetes·Jussi HirvonenPirjo Nuutila
Jan 25, 2012·The Journal of Clinical Investigation·Véronique OuelletAndré C Carpentier
Aug 2, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Anne VriezeFrits Holleman
May 31, 2013·The American Journal of Clinical Nutrition·Maarten J VosselmanWouter D van Marken Lichtenbelt
Dec 29, 2013·Journal of Lipid Research·Michal Herman-EdelsteinUzi Gafter
Jan 31, 2014·Diabetologia·Heiko Bugger, E Dale Abel
Mar 22, 2014·Diabetes·Claudio CobelliRobert Rizza
Apr 25, 2014·American Journal of Physiology. Endocrinology and Metabolism·Sébastien M LabbéAndré C Carpentier
Aug 2, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Fabian DemeureDavid Vancraeynest
Nov 12, 2014·Frontiers in Endocrinology·Jonas Sieber, Andreas Werner Jehle

❮ Previous
Next ❯

Citations

Oct 14, 2017·Journal of Applied Physiology·Vera B Schrauwen-Hinderling, Annemie M W J Schols
Aug 23, 2018·Frontiers in Endocrinology·André C CarpentierÉric E Turcotte
Nov 17, 2019·Food Research International·Lia Silveira AdrianoHelena Alves de Carvalho Sampaio

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.