Molecular imaging of serotonin degeneration in mild cognitive impairment

Neurobiology of Disease
Gwenn S SmithClifford I Workman

Abstract

Neuropathological and neuroimaging studies have consistently demonstrated degeneration of monoamine systems, especially the serotonin system, in normal aging and Alzheimer's disease. The evidence for degeneration of the serotonin system in mild cognitive impairment is limited. Thus, the goal of the present study was to measure the serotonin transporter in vivo in mild cognitive impairment and healthy controls. The serotonin transporter is a selective marker of serotonin terminals and of the integrity of serotonin projections to cortical, subcortical and limbic regions and is found in high concentrations in the serotonergic cell bodies of origin of these projections (raphe nuclei). Twenty-eight participants with mild cognitive impairment (age 66.6±6.9, 16 males) and 28 healthy, cognitively normal, demographically matched controls (age 66.2±7.1, 15 males) underwent magnetic resonance imaging for measurement of grey matter volumes and high-resolution positron emission tomography with well-established radiotracers for the serotonin transporter and regional cerebral blood flow. Beta-amyloid imaging was performed to evaluate, in combination with the neuropsychological testing, the likelihood of subsequent cognitive decline in the par...Continue Reading

Citations

Oct 7, 2017·Journal of Alzheimer's Disease : JAD·Costa Vakalopoulos
Dec 13, 2018·Acta Neuropathologica Communications·Christian KleinAyikoe-Guy Mensah-Nyagan
Oct 18, 2019·Expert Opinion on Drug Discovery·Miroslava Cuperlovic-Culf, Amanpreet Badhwar
May 2, 2018·Journal of Alzheimer's Disease : JAD·Nicole CortésRicardo B Maccioni
May 14, 2020·International Journal of Geriatric Psychiatry·Rayna B HirstRuth O'Hara
Oct 1, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Daniel R BatemanUNKNOWN International Society to Advance Alzheimer's Research and Treatment (ISTAART), Neuropsychiatric Syndromes Professional Inter
Oct 13, 2020·Journal of Alzheimer's Disease : JAD·Melanie HüttenrauchSusana Castro-Obregón
Feb 17, 2021·Neurobiology of Aging·Gwenn S SmithClifford I Workman
Jan 28, 2021·Seminars in Nuclear Medicine·Aren van WaardeRudi A J O Dierckx
May 1, 2021·Journal of Clinical Medicine·Ágoston PatthyAlán Alpár
Jun 3, 2021·International Journal of Molecular Sciences·Ekaterina A LitusSergei E Permyakov
Aug 30, 2021·The Journal of Infection·Che-Sheng ChuMu-Hong Chen

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