PMID: 20639816Jul 20, 2010Paper

Molecular imaging of αvß3 expression in cancer patients

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica
F C GaertnerAmbros J Beer

Abstract

Angiogenesis, the formation of new blood vessels, is a key process in the growth of solid tumors. Thus this process could potentially be utilized for diagnosis of malignancies by molecular imaging on the one hand and for tumor treatment on the other hand. Imaging of angiogenesis has become increasingly important with the rising use of targeted antiangiogenic therapies, like bevacizumab (Avastin). Non-invasive assessment of angiogenic activity is in this respect interesting e.g. for response assessment of such targeted antiangiogenic therapies. Several methods have been employed for imaging of angiogenesis in vivo. Mostly these approaches measure physical parameters of the tissue, e.g. blood flow, blood volume and vessel permeability. Another approach of angiogenesis imaging is imaging of specific molecular markers of the angiogenic cascade. Integrins, like αvß3, but also αvß5 and α5ß1, play a central role in the angiogenic process and integrin αvß3 binding substances can be used as imaging probes to assess integrin expression. For clinical applications, the use of radiolabeled integrin binding substances is favorable, as radiotracers can be detected with very high sensitivities in vivo. As the radiotracer approach for molecular...Continue Reading

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Related Papers

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica
F C GaertnerAmbros J Beer
European Journal of Nuclear Medicine and Molecular Imaging
F C GaertnerAmbros J Beer
The British Journal of Radiology
Sally L Pimlott, K P Ebmeier
© 2021 Meta ULC. All rights reserved