Molecular Imaging of Very Late Antigen-4 in Acute Lung Injury.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Joseph HaddadSina Tavakoli

Abstract

Inflammation plays a central role in the pathogenesis of acute lung injury (ALI) during both the acute pneumonitis stage and progression into the chronic fibroproliferative phase, leading to pulmonary fibrosis. Currently, there is an unmet clinical and research need for noninvasive ways to monitor lung inflammation through targeting of immunoregulatory pathways contributing to ALI pathogenesis. In this study, we evaluated the role of targeted imaging of very late antigen-4 (VLA-4), as a key integrin mediating the adhesion and recruitment of immune cells to inflamed tissues, in quantifying lung inflammation in a mouse model of lipopolysaccharide-induced ALI. Methods: ALI was induced by a single intratracheal administration of lipopolysaccharide (10, 20, or 40 μg per mouse) in C57BL/6J mice. Control mice were intratracheally instilled with sterile phosphate-buffered saline. VLA-4-targeted PET/CT was performed 24 h after intravenous injection of a 64Cu-labeled high-affinity peptidomimetic ligand referred to as 64Cu-LLP2A, which is conjugated with the chelator (1,4,8,11-tetraazacyclotetradecane-1-(methane phosphonic acid)-8-(methane carboxylic acid) and a polyethylene glycol 4 linker, at day 2 after the induction of ALI. Ex vivo bi...Continue Reading

References

Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C G FengA G Bean
Feb 6, 2003·American Journal of Respiratory and Critical Care Medicine·Gloria C KooIrwin I Singer
Oct 21, 2005·The New England Journal of Medicine·Gordon D RubenfeldLeonard D Hudson
Dec 24, 2008·European Journal of Pharmacology·Nicholas J KenyonKit S Lam
Jan 16, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Elizabeth R Johnson, Michael A Matthay
Aug 21, 2010·American Journal of Respiratory Cell and Molecular Biology·Jessica R Walrath, Richard F Silver
Mar 2, 2011·Disease Models & Mechanisms·Alastair G ProudfootMatthew Hind
Mar 29, 2011·Critical Care Clinics·L J Mark Cross, Michael A Matthay
Apr 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aras KadiogluNancy Hogg
Sep 29, 2012·Respiration; International Review of Thoracic Diseases·Teresa TrottaMassimo Conese
Mar 23, 2013·The European Respiratory Journal·Ellen L BurnhamGregory P Downey
Jul 28, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sina TavakoliReto Asmis
Sep 27, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wissam Beaino, Carolyn J Anderson
Nov 7, 2014·American Journal of Respiratory Cell and Molecular Biology·Wei HanTimothy S Blackwell
Jan 9, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Deepti SoodguptaMonica Shokeen
Aug 26, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amarjit MishraLin Liu
Oct 22, 2016·The Journal of Trauma and Acute Care Surgery·Pauline K ParkLena M Napolitano
Jun 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua T MattilaCarolyn J Anderson
Sep 28, 2017·PloS One·Natália de Souza Xavier CostaLuiz Fernando Ferraz da Silva
Jul 1, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jaeyeon ChoiCarolyn J Anderson
Feb 24, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Qizhen CaoChun Li
May 6, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Anja BrauneMarcelo Gama de Abreu

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May 27, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hong WangShanshan Huang

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