Molecular imaging

Radiology
R Weissleder, U Mahmood

Abstract

The term molecular imaging can be broadly defined as the in vivo characterization and measurement of biologic processes at the cellular and molecular level. In contradistinction to "classical" diagnostic imaging, it sets forth to probe the molecular abnormalities that are the basis of disease rather than to image the end effects of these molecular alterations. While the underlying biology represents a new arena for many radiologists, concomitant efforts such as development of novel agents, signal amplification strategies, and imaging technologies clearly dovetail with prior research efforts of our specialty. Radiologists will play a leading role in directing developments of this embryonic but burgeoning field. This article presents some recent developments in molecular sciences and medicine and shows how imaging can be used, at least experimentally, to assess specific molecular targets. In the future, specific imaging of such targets will allow earlier detection and characterization of disease, earlier and direct molecular assessment of treatment effects, and a more fundamental understanding of the disease process.

References

May 28, 1992·The New England Journal of Medicine·R A EzekowitzJ Folkman
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A P KoretskyT Van Dyke
Jan 1, 1986·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·D A GoodwinJ P Leung
Dec 14, 1995·Nature·M Wadman
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·G NilaverE A Neuwelt
Jan 1, 1995·Cancer Investigation·R A FiglinA Belldegrun
Jun 1, 1995·The Journal of Investigative Dermatology·M RajadhyakshaR R Anderson
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·D H TurnbullA L Joyner
Apr 1, 1994·Neurosurgery·E A NeuweltC I McCormick
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·D A BoasA G Yodh
Jan 1, 1994·The Annals of Otology, Rhinology, and Laryngology·L A OhlmsG B Healy
Jan 1, 1993·Acta Oncologica·S E StrandK Sjögreen
Nov 1, 1995·British Journal of Urology·M PerrottiV S Mandell
Jan 1, 1996·Calcified Tissue International·P RüegseggerR Müller
Oct 1, 1995·Brain Pathology·C M KrammX O Breakefield
Dec 27, 1996·Cell·J Folkman, P A D'Amore
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·R BraschO Melnyk
Jan 1, 1997·Cardiovascular Research·O TahlilP G Steg
Apr 1, 1997·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·J P VuillezC Brambilla
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A BoppartJ G Fujimoto
Jun 27, 1997·Science·G J TearneyJ G Fujimoto
Nov 1, 1994·Nuclear Medicine and Biology·D J HnatowichP Winnard
Aug 1, 1997·Radiology·W S EnochsR Weissleder
Jul 1, 1997·Nuclear Medicine and Biology·P WinnardD J Hnatowich
Oct 24, 1997·Photochemistry and Photobiology·C H ContagD A Benaron
Feb 14, 1998·Nature Medicine·P R ContagC H Contag
Feb 21, 1998·Trends in Biotechnology·A Bogdanov, R Weissleder
Apr 16, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleR M Weisskoff
Apr 18, 1998·Biochimica Et Biophysica Acta·A BogdanovR Weissleder
Apr 29, 1998·Ultrasound in Medicine & Biology·K Hynynen, F A Jolesz
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·F G BlankenbergH W Strauss
Jun 2, 1998·Biochimica Et Biophysica Acta·A MooreR Weissleder
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S E SlawsonA P Koretsky
Jul 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J RuffA Haase
Aug 7, 1998·Human Gene Therapy·D SchellingerhoutR Weissleder

❮ Previous
Next ❯

Citations

Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Frank W Pfrieger
Jan 29, 2003·Journal of Cellular Biochemistry. Supplement·D J Hnatowich
Jan 29, 2003·Journal of Cellular Biochemistry. Supplement·A H JacobsW D Heiss
Jan 29, 2003·Journal of Cellular Biochemistry. Supplement·Yasuhisa FujibayashiYoshiharu Yonekura
Jan 29, 2003·Journal of Cellular Biochemistry. Supplement·R J Gillies
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·King C P Li
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Anwar R Padhani
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Silvio AimeFabio Maggioni
May 23, 2006·Der Radiologe·M H BremP Lang
Jan 5, 2007·Der Radiologe·L MatuszewskiC Bremer
Sep 16, 2010·Der Radiologe·K PinkerT H Helbich
Mar 30, 2010·Analytical and Bioanalytical Chemistry·Ravindran Girija AswathyD Sakthi Kumar
Sep 8, 2010·Pediatric Radiology·Peter Brader
Sep 30, 2010·Pediatric Radiology·Nicolas Grenier, Peter Brader
Dec 4, 2010·Pediatric Radiology·Carola Heneweer, Jan Grimm
Sep 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Uwe Haberkorn, Michael Eisenhut
May 5, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Takahiro HiguchiMarkus Schwaiger
Sep 12, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Weibo CaiXiaoyuan Chen
Apr 29, 2008·European Journal of Nuclear Medicine and Molecular Imaging·UNKNOWN Netherlands Society for Nuclear Medicine (NVNG), UNKNOWN Radiological Society of the Netherlands (NVvR)
Mar 11, 2005·Abdominal Imaging·T PersigehlC Bremer
May 3, 2013·Cardiovascular and Interventional Radiology·Charles R Tapping, Mark J Bratby
Oct 6, 2006·European Radiology·Gabriel P Krestin, Monique R Bernsen
Jul 20, 2007·European Radiology·Jens BremerichPeter Reimer
Jan 21, 2009·European Radiology·Nicolas GrenierGabriel P Krestin
Mar 14, 2009·European Radiology·S TrattnigF Eckstein
Nov 12, 2005·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Oct 1, 2008·Histochemistry and Cell Biology·Paul Debbage, Werner Jaschke
Dec 24, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Simonetta Geninatti CrichSilvio Aime
Sep 13, 2005·Magma·G J StrijkersK Nicolay
Apr 13, 2010·Angiogenesis·Jacobus F A JansenAmita Shukla-Dave
Jun 17, 2010·Angiogenesis·Willem J M MulderArjan W Griffioen
Jun 19, 2010·Angiogenesis·Willem J M Mulder, Arjan W Griffioen
May 29, 2008·Cancer Metastasis Reviews·Dominique JenningsRobert J Gillies
Feb 1, 2011·Journal of Materials Science. Materials in Medicine·Gang LiuZhongwei Gu
Jan 10, 2012·Journal of Fluorescence·Aby Cheruvathoor PouloseD Sakthi Kumar
Jan 5, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·B J SchallerM Buchfelder
Dec 3, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Chia-Lin ChenBenjamin M W Tsui

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.