Molecular implications in the nanoencapsulation of the anti-tuberculosis drug rifampicin within flower-like polymeric micelles

Colloids and Surfaces. B, Biointerfaces
Marcela A MorettonAlejandro Sosnik

Abstract

Tuberculosis (TB) is the second most deadly infectious disease behind the Human Immunodeficiency Virus (HIV). An effective pharmacotherapy has been available for more than 5 decades. However, the length of the treatment and the pill burden result in low patient compliance and adherence to the regimens. Nanotechnologies can overcome these basic technological drawbacks. The present work explored the molecular implications governing the encapsulation and water solubilization of RIF within flower-like micelles of poly(epsilon-caprolactone)-b-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) block copolymers. Ten derivatives of different molecular weight and hydrophobic/hydrophilic caprolactone/ethylene oxide ratio (CL/EO) were synthesized by a fast and high-yield Microwave-Assisted Polymer Synthesis (MAPS) technique; CL/EO values are determined by taking the ratios of the number of repeating units in the PCL and the PEG segments. The aggregation behavior of the copolymers was thoroughly investigated by means of surface tension (critical micellar concentration), dynamic light scattering (size, size distribution and zeta potential) and transmission electron microscopy (morphology). In general, the greater the central PEG...Continue Reading

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Citations

Aug 26, 2011·Journal of the Royal Society, Interface·Marcela A MorettonAlejandro Sosnik
Aug 31, 2013·International Journal of Nanomedicine·Mithun Varghese VadakkanG S Vinod Kumar
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Katia P SeremetaAlejandro Sosnik
Sep 26, 2013·Colloids and Surfaces. B, Biointerfaces·Ezequiel BernabeuDiego A Chiappetta
Jan 20, 2012·Expert Opinion on Drug Delivery·Alejandro SosnikDiego A Chiappetta
Mar 22, 2016·RSC Advances·Aline A IshikawaCarlos D Garcia
Feb 19, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Rajesh Pandey, Zahoor Ahmad
Nov 23, 2015·Colloids and Surfaces. B, Biointerfaces·Marcela A MorettonDiego A Chiappetta
Sep 19, 2015·Pharmaceutical Research·Avinash GothwalUmesh Gupta
Jan 20, 2015·Biotechnology Advances·Alejandro Sosnik, Maya Menaker Raskin
May 14, 2014·Advanced Drug Delivery Reviews·Alejandro Sosnik, Angel M Carcaboso
Jul 19, 2016·Colloids and Surfaces. B, Biointerfaces·Paula TaichPaula Schaiquevich
Jul 20, 2016·The Journal of Pharmacy and Pharmacology·Marcel WegmannMarcela A Moretton
Feb 18, 2017·Tuberculosis Research and Treatment·Mohammad NasiruddinShilpi Das
Jun 14, 2018·Biomaterials Science·Rui ZhangBret D Ulery
Feb 8, 2019·Current Pharmaceutical Design·Mohini MishraAmit Modgil
Jun 21, 2019·Current Pharmaceutical Design·Prasad MinakshiGaya Prasad
Sep 22, 2018·Pharmaceutical Research·Estefania GrotzMarcela A Moretton
Apr 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Poulomi DeyAiyagari Ramesh
Jul 28, 2017·Therapeutic Advances in Infectious Disease·Lavanya SinghRaveen Parboosing
Jul 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nataliya Kuplennik, Alejandro Sosnik
Jun 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Romina J GlisoniAlejandro Sosnik
Dec 10, 2020·Expert Opinion on Drug Metabolism & Toxicology·Nagarani ThotakuraKaisar Raza
Dec 29, 2020·Journal of Microbiological Methods·Madushani H Dahanayake, Anil C A Jayasundera
Mar 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·M GhezziS Nicoli
Nov 14, 2020·Cellular and Molecular Bioengineering·Nirmalya TripathyEun Ji Chung

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