Molecular Insights into Antimicrobial Resistance Traits of Multidrug Resistant Enteric Pathogens isolated from India.

Scientific Reports
Pawan KumarBhabatosh Das

Abstract

Emergence of antimicrobial resistant Gram-negative bacteria has created a serious global health crisis and threatens the effectiveness of most, if not all, antibiotics commonly used to prevent and treat bacterial infections. There is a dearth of detailed studies on the prevalence of antimicrobial resistance (AMR) patterns in India. Here, we have isolated and examined AMR patterns of 654 enteric pathogens and investigated complete genome sequences of isolates from six representative genera, which in aggregate encode resistance against 22 antibiotics representing nine distinct drug classes. This study revealed that ~97% isolates are resistant against ≥2 antibiotics, ~24% isolates are resistant against ≥10 antibiotics and ~3% isolates are resistant against ≥15 antibiotics. Analyses of whole genome sequences of six extensive drug resistant enteric pathogens revealed presence of multiple mobile genetic elements, which are physically linked with resistance traits. These elements are therefore appearing to be responsible for disseminating drug resistance among bacteria through horizontal gene transfer. The present study provides insights into the linkages between the resistance patterns to certain antibiotics and their usage in India....Continue Reading

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Citations

Mar 15, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jyoti VermaBhabatosh Das
Jul 17, 2018·Microbial Ecology·Satyabrata BagBhabatosh Das
Jun 9, 2020·Frontiers in Cell and Developmental Biology·Melissa EmamalipourPeyman Zare
Sep 30, 2018·Scientific Reports·Vitalij NovickijIrutė Girkontaitė
Jun 29, 2021·MicrobiologyOpen·Shalini KunhikannanSteve Petrovski
Jul 20, 2021·Frontiers in Microbiology·Dipanjan DuttaSatyabrata Bag
May 17, 2021·Ecotoxicology·Lateef Babatunde SalamOlukayode Oladipo Amund

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Datasets Mentioned

BETA
KX302888.1
KX302887.1
KX302886.1
KX302885.1
KX302884.1
KX302883.1

Methods Mentioned

BETA
DNA exchange
phosphotransferase
electrophoresis
PCR

Software Mentioned

GS de novo genome assembler
RAST
R package
R

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