PMID: 9650444Jul 3, 1998Paper

Molecular interaction between factor VII and tissue factor

International Journal of Hematology
S Higashi, S Iwanaga

Abstract

Complex formation between serine protease factor VIIa (VIIa) and tissue factor (TF) dramatically enhances the catalytic activity of VIIa, leading to the initiation of extrinsic blood coagulation. The recently determined crystal structure of the complex formed between VIIa and the extracellular domain of TF has revealed in detail the interacting surfaces of the two molecules. Mutational and biochemical studies have further identified regions of VIIa and/or those of TF essential for the high affinity interaction. These studies indicate that the regions extending from the gamma-carboxyglutamic acid domain through the first epidermal growth factor-like domain and protease domain of VIIa are involved separately in the interaction with the distinct sites of TF. The interaction of TF with the protease domain of VIIa apparently induces a conformational transition of the VIIa active site. Studies of the chemical modification of VIIa provided a model for the mechanism of TF-mediated acceleration of VIIa activity. In this model, the protease domain of VIIa exists in equilibrium between minor active and dominant zymogen-like inactive conformational states, and preferential binding of TF to the active state leads to a shift in equilibrium i...Continue Reading

Citations

Apr 13, 2000·Nature·M S DennisR A Lazarus
Apr 17, 2001·The Annals of Pharmacotherapy·T Y Chan
Mar 27, 2002·Journal of Computational Chemistry·Lalith PereraLee G Pedersen
Jan 26, 2005·British Journal of Haematology·Jeff HewittRoss T A MacGillivray
Apr 21, 2004·Anaesthesia·G C PriceP C A Kam
Aug 18, 2009·The Journal of Urology·Elinês O MacielBernardo Garicochea
Jun 13, 2000·Protein Science : a Publication of the Protein Society·L C PetersenE Persson
Mar 10, 2004·International Journal of Hematology·James H Morrissey
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·C P SommerhoffA Bergner
Dec 6, 2018·Revista do Colégio Brasileiro de Cirurgiões·Marcelo Garcia TonetoGustavo Franco Carvalhal
Mar 10, 2000·Biochimica Et Biophysica Acta·C P SommerhoffH Fritz

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