Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics

PloS One
Zeenat MirzaSajjad Karim

Abstract

The S100A8 and epidermal growth factor receptor (EGFR) proteins are proto-oncogenes that are strongly expressed in a number of cancer types. EGFR promotes cellular proliferation, differentiation, migration and survival by activating molecular pathways. Involvement of proinflammatory S100A8 in tumor cell differentiation and progression is largely unclear and not studied in kidney cancer (KC). S100A8 and EGFR are potential therapeutic biomarkers and anticancer drug targets for KC. In this study, we explored molecular mechanisms of interaction profiles of both molecules with potential anticancer drugs. We undertook transcriptional profiling in Saudi KCs using Affymetrix HuGene 1.0 ST arrays. We identified 1478 significantly expressed genes, including S100A8 and EGFR overexpression, using cut-off p value <0.05 and fold change ≥2. Additionally, we compared and confirmed our findings with expression data available at NCBI's GEO database. A significant number of genes associated with cancer showed involvement in cell cycle progression, DNA repair, tumor morphology, tissue development, and cell survival. Atherosclerosis signaling, leukocyte extravasation signaling, notch signaling, and IL-12 signaling were the most significantly disrup...Continue Reading

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Citations

Jan 17, 2016·BMC Medical Genetics·Natália BertoniPatricia P Reis
Apr 17, 2012·Experimental Parasitology·Zengmei SongChangwang Pan
Feb 26, 2016·International Journal of Molecular Sciences·Sajjad KarimMohammed H Al-Qahtani
Jun 2, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Sarah M PetersonLucy Liaw
Jul 10, 2020·Journal of Biomolecular Structure & Dynamics·Bhavana JonnalagaddaAbhinand P A

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Datasets Mentioned

BETA
GSE6344
GSE7023

Methods Mentioned

BETA
co-crystallization
surgical resections
interaction studies

Software Mentioned

Partek Genomics Suite
Molecular Docking Server
Ingenuity Pathways Analysis software ( IPA
AutoDock
IPA
PyMOL
Autogrid

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