Molecular interactions between gold nanoparticles and model cell membranes

Physical Chemistry Chemical Physics : PCCP
Peipei HuZhan Chen

Abstract

The interactions between nanoparticles (NPs) and cells are of huge interest because NPs have been extensively researched for biomedical applications. For the cellular entry of NPs, it remains unclear how the cell membrane molecules respond to the exposure of NPs due to a lack of appropriate surface/interface-sensitive techniques to study NP-cell membrane interactions in situ in real time. In this study, sum frequency generation (SFG) vibrational spectroscopy was employed to examine the interactions between lipid bilayers (serving as model mammalian cell membranes) and Au NPs of four different sizes with the same mass, or the same NP number, or the same NP surface area. It was found that lipid flip-flop was induced by Au NPs of all four sizes. Interestingly, the lipid flip-flop rate was found to increase as the Au NP size increased with respect to the same particle number or the same NP surface area. However, the induced lipid flip-flop rate was the same for Au NPs with different sizes with the same mass, which was interpreted by the same "effective surface contact area" between Au NPs and the model cell membrane. We believe that this study provided the first direct observation of the lipid flip-flop induced by the interactions ...Continue Reading

References

Jan 1, 1985·Biophysical Journal·L K Tamm, H M McConnell
Jan 1, 1999·Chemistry and Physics of Lipids·J L Arrondo, F M Goñi
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K S SoppimathW E Rudzinski
Sep 3, 2002·Advanced Drug Delivery Reviews·Irène BriggerPatrick Couvreur
Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Jul 9, 2004·Journal of the American Chemical Society·Jin Liu, John C Conboy
Mar 10, 2006·Biochimica Et Biophysica Acta·Xiaoyun Chen, Zhan Chen
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
May 30, 2006·Biochimica Et Biophysica Acta·Richard MendelsohnDavid J Moore
Jun 26, 2007·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Jul 26, 2008·Nature Nanotechnology·Wen JiangWarren C W Chan
Sep 3, 2008·Chemical Society Reviews·Ralph A SperlingWolfgang J Parak
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bo WangSteve Granick
May 8, 2009·Physical Chemistry Chemical Physics : PCCP·Qifeng LiKeng C Chou
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Jul 18, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sneha SundaramUday B Kompella
Sep 5, 2009·The Journal of Physical Chemistry. B·Khoi Tan NguyenZhan Chen
Oct 22, 2009·Small·Ayush Verma, Francesco Stellacci
Jan 16, 2010·The Journal of Physical Chemistry. B·Timothy C AnglinJohn C Conboy
Feb 16, 2010·Journal of Toxicology and Environmental Health. Part a·Erik K RushtonGünter Oberdörster
Aug 3, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Zheng YangKeng C Chou
Aug 28, 2010·Nanotoxicology·Tatsiana MironavaMiriam H Rafailovich
May 21, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Pei YangZhan Chen
Jun 10, 2011·Nature·Igor V StiopkinAlexander V Benderskii
Jun 21, 2011·Chemical Communications : Chem Comm·Yuping ShanHongda Wang
Jan 1, 2010·Nano Reviews·Raphaël LévyViolaine Sée
Jan 17, 2012·Environmental Science & Technology·Wen-Che HouJonathan D Posner
Mar 7, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Bonnie O LeungKeng C Chou

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Citations

May 8, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Renee V GorehamIngo Köper
Mar 16, 2019·Materials·Christophe HumbertGrégory Barbillon
Dec 14, 2017·Physical Chemistry Chemical Physics : PCCP·Yaoxin LiZhan Chen
Mar 24, 2021·Journal of Colloid and Interface Science·Nicola WilliamLaurence Andrew Nelson
May 21, 2021·Colloids and Surfaces. B, Biointerfaces·Rafael Leonardo C G da SilvaLuciano Caseli
Nov 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Ridwan P PutraIzabela I Rzeznicka

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