Molecular interactions of exogenous chemical agents with collagen--implications for tissue optical clearing

Journal of Biomedical Optics
Alvin T Yeh, Jason Hirshburg

Abstract

Reduction of optical scattering in turbid biological tissues using nonreactive chemical agents has potential applications for light-based diagnostics and therapeutics. Optical clearing effects by exogenous chemical agents, in particular sugars and sugar alcohols, have been found to be temporary with tissue rehydration. Applications with dermatologic laser therapies are now being investigated, but suffer from the inability of studied agents to penetrate the superficial layers of human skin. Selection, design, and refinement of topically effective chemical agents are hindered by a lack of fundamental understanding of tissue clearing mechanisms. We present recent work, particularly from the biochemistry community, detailing molecular interactions between chemical agents and collagen. This body of work demonstrates the perturbative effects of sugars and sugar alcohols on collagen high-order structures at micro- and nanometer length scales by screening noncovalent bonding forces. In addition, these studies emphasize the nonreactive nature of agent-collagen interactions and the ability of noncovalent bonding forces to recover with agent removal and drive reassembly of destabilized collagen structures. A mechanism of tissue optical cl...Continue Reading

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Citations

Apr 16, 2010·Lasers in Medical Science·Changmin YeoByungjo Jung
Mar 6, 2010·Photochemistry and Photobiology·Huiqing ZhongSonghao Liu
Sep 13, 2006·Journal of Biomedical Optics·Jason HirshburgAlvin T Yeh
May 10, 2008·Journal of Biomedical Optics·Zongzhen MaoZhenzhen Han
May 10, 2008·Journal of Biomedical Optics·Matthew V SchulmerichSteven A Goldstein
Nov 9, 2010·Journal of Biomedical Optics·Jason M HirshburgAlvin T Yeh
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Apr 29, 2016·Journal of Biomedical Optics·Valery V Tuchin
Jan 27, 2018·Journal of Molecular Modeling·Kirill V BerezinValery V Tuchin
Nov 26, 2009·Journal of Biophotonics·Xiang WenDan Zhu
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Oct 28, 2019·Biomedical Optics Express·Irene CostantiniFrancesco Saverio Pavone
Feb 22, 2007·Lasers in Surgery and Medicine·Jason HirshburgAlvin T Yeh
Mar 16, 2021·IScience·Tingting YuDan Zhu

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