Molecular investigations of development and diseases of the brain of higher mammals using the ferret

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Hiroshi Kawasaki

Abstract

The brains of higher mammals such as primates and carnivores contain well-developed unique brain structures. Uncovering the physiological functions, developmental mechanisms and evolution of these brain structures would greatly facilitate our understanding of the human brain and its diseases. Although the anatomical and electrophysiological features of these brain structures have been intensively investigated, our knowledge about their molecular bases is still limited. To overcome this limitation, genetic techniques for the brains of carnivores and primates have been established, and molecules whose expression patterns correspond to these brain structures were identified recently. To investigate the functional roles of these molecules, rapid and efficient genetic manipulation methods for higher mammals have been explored. In this review, recent advances in molecular investigations of the brains of higher mammals are discussed, mainly focusing on ferrets (Mustela putorius furo).

References

Oct 1, 1990·Trends in Neurosciences·P H Schiller, N K Logothetis
Mar 1, 1968·The Journal of Physiology·D H Hubel, T N Wiesel
Nov 1, 1965·Journal of Neurophysiology·T N Wiesel, D H Hubel
Jun 18, 1993·Science·A Antonini, M P Stryker
Nov 18, 2000·Science·J C Crowley, L C Katz
Sep 22, 2001·Science·T Fukuchi-Shimogori, E A Grove
Feb 2, 2002·Nature Reviews. Neuroscience·Lawrence C Katz, Justin C Crowley
Aug 15, 2002·Cell·Hynek WichterleThomas M Jessell
Jun 20, 2003·Journal of Neurocytology·Javier DeFelipeJon I Arellano
Nov 1, 1963·Journal of Neurophysiology·T N WIESEL, D H HUBEL
Jul 26, 2008·Development·Ayane Kataoka, Tomomi Shimogori
May 30, 2009·Nature·Erika SasakiTatsuji Nomura
Feb 16, 2010·Nature·David V HansenArnold R Kriegstein
Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Keisuke SeharaHiroshi Kawasaki
Jul 7, 2011·Cell·Jan H LuiArnold R Kriegstein
Dec 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas E KraheWilliam Guido
Jan 11, 2012·Progress in Brain Research·Zoltán Molnár, Gavin Clowry
Mar 20, 2012·Brain : a Journal of Neurology·A James BarkovichWilliam B Dobyns
Mar 27, 2012·Neuron·Amy BernardEd S Lein
Apr 30, 2013·The EMBO Journal·Miki Nonaka-KinoshitaFederico Calegari
Jul 6, 2013·Science·Annapurna PoduriChristopher A Walsh
Jul 30, 2014·Frontiers in Neural Circuits·Jihane Homman-Ludiye, James A Bourne
Nov 20, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Takashi Namba, Wieland B Huttner

❮ Previous
Next ❯

Citations

Jan 13, 2018·Human Molecular Genetics·Naoyuki MatsumotoHiroshi Kawasaki
Mar 2, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroshi Kawasaki
Mar 19, 2021·Biochemistry and Biophysics Reports·Hiroki MaeyamaHiroshi Kawasaki

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.