Molecular level investigation of organization in ternary lipid bilayer: a computational approach

Langmuir : the ACS Journal of Surfaces and Colloids
Sumita Mondal, Chaitali Mukhopadhyay

Abstract

The differential organization of lipid components in a multicomponent membrane leads to formation of domains having diverse composition and size. Cholesterol and glycosphingolipids are known to be important components of such lateral assembly. We report here the ordering of cholesterol around ganglioside GM1 and the nature of the cluster from an all-atom simulation of a ternary lipid system. The results are compared with a binary bilayer and a pure phospholipid bilayer. The difference in molecular rearrangements in ternary and binary lipid mixture shows the role of GM1 in the rearrangement of cholesterol. Calculation of the radial distribution function, rotational reorientation, and residence time analysis of cholesterol shows that cholesterol is preferentially accumulating near gangliosides, while the lateral translational motion, rotational diffusion, and order parameter of phospholipids characterize the amount of rigidity imparted on the phospholipid bilayer.

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·T B Woolf, B Roux
Jul 27, 2000·Journal of Cellular Physiology·R N KolesnickA Alonso
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A RadhakrishnanH M McConnell
Mar 15, 2001·Biochimica Et Biophysica Acta·A RadhakrishnanH M McConnell
Sep 27, 2002·Biophysical Journal·S W ChiuH Larry Scott
Apr 2, 2003·Biophysical Journal·Christofer HofsässOlle Edholm
May 9, 2003·The Journal of Biological Chemistry·Nicoletta KahyaPetra Schwille
Aug 29, 2003·Biophysical Journal·Mitsuhiro HiraiHiroshi Takahashi
Aug 29, 2003·Biophysical Journal·Holly C Gaede, Klaus Gawrisch
Sep 26, 2003·Biophysical Journal·Rodrigo F M de AlmeidaManuel Prieto
Nov 5, 2003·Journal of Lipid Research·Tomasz RógMarta Pasenkiewicz-Gierula
Nov 19, 2003·Cell·Sean Munro
Mar 3, 2004·Biophysical Journal·Juha M HolopainenPaavo K J Kinnunen
Aug 10, 2004·Biophysical Journal·Sagar A PanditH L Scott
Nov 10, 2004·Biophysical Journal·Ryan W BenzStephen H White
Aug 3, 2005·Journal of Biomolecular Structure & Dynamics·Chiradip Chatterjee, Chaitali Mukhopadhyay
Aug 5, 2005·Nature·Ben Nichols
Oct 18, 2005·Biochimica Et Biophysica Acta·Claudia R BollingerErich Gulbins
Jan 10, 2006·Biophysical Journal·Jacek Czub, Maciej Baginski
Jan 18, 2006·The Journal of Chemical Physics·Sagar A Pandit, H Larry Scott
Mar 28, 2006·Biophysical Journal·Salvatore ChiantiaPetra Schwille
Apr 11, 2006·The Journal of Membrane Biology·Norbert KucerkaJohn F Nagle
Apr 21, 2006·Nature Reviews. Molecular Cell Biology·John F Hancock
Aug 22, 2006·Biophysical Journal·Tomasz Róg, Marta Pasenkiewicz-Gierula
Sep 20, 2006·Glycobiology·Sandro SonninoAlessandro Prinetti
Jan 19, 2007·The Journal of Physical Chemistry. B·Sarah L VeatchJenifer L Thewalt
Apr 10, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Carolyn M McQuawNicholas Winograd
Apr 13, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Linda J Johnston
May 5, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Oana CobanLinda J Johnston
Jun 15, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Salvatore ChiantiaPetra Schwille
Jun 26, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Mikkel Herholdt JensenAdam Cohen Simonsen
Sep 28, 2007·Seminars in Cell & Developmental Biology·Daniel AbankwaJohn F Hancock
Apr 30, 1998·The Journal of Physical Chemistry. B·A D MacKerellM Karplus

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Citations

Jan 11, 2014·Biochimica Et Biophysica Acta·Moutusi MannaIlpo Vattulainen
Jan 15, 2016·Biochimica Et Biophysica Acta·Alexander P Lyubartsev, Alexander L Rabinovich
Mar 5, 2016·Journal of the American Chemical Society·Nikolay SmolentsevSylvie Roke
Dec 3, 2014·Chemistry and Physics of Lipids·Tomasz Róg, Ilpo Vattulainen
Jun 13, 2015·Physical Chemistry Chemical Physics : PCCP·Ipsita Basu, Chaitali Mukhopadhyay
Aug 16, 2014·Frontiers in Endocrinology·Sandra Merscher, Alessia Fornoni
Apr 11, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Taras SychWinfried Römer
Apr 6, 2012·Physical Biology·M BallyF Höök
Jul 28, 2018·Biochimica Et Biophysica Acta. Biomembranes·Alexandra Schumann-Gillett, Megan L O'Mara
May 26, 2010·The Journal of Physical Chemistry. B·Anette HallIlpo Vattulainen
Sep 17, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Moutusi Manna, Chaitali Mukhopadhyay
Nov 27, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Ipsita Basu, Chaitali Mukhopadhyay
Aug 10, 2019·The Journal of Physical Chemistry. B·Michael C OwenRobert Vácha
Dec 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Ipsita Basu, Prabal K Maiti
Dec 12, 2018·Journal of Chemical Theory and Computation·Jumin LeeWonpil Im

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