Molecular-level tradeoffs and metabolic adaptation to simultaneous stressors.

Current Opinion in Biotechnology
Ross P Carlson, Reed Taffs

Abstract

Life is a dynamic process driven by the complex interplay between physical constraints and selection pressures, ranging from nutrient limitation to inhibitory substances to predators. These stressors are not mutually exclusive; microbes have faced concurrent challenges for eons. Genome-enabled systems biology approaches are adapting economic and ecological concepts like tradeoff curves and strategic resource allocation theory to analyze metabolic adaptations to simultaneous stressors. These methodologies can accurately describe and predict metabolic adaptations to concurrent stresses by considering the tradeoff between investment of limiting resources into enzymatic machinery and the resulting cellular function. The approaches represent promising links between computational biology and well-established economic and ecological methodologies for analyzing the interplay between physical constraints and microbial fitness.

References

Feb 1, 1978·Biotechnology and Bioengineering·F G Bader
May 14, 1999·Current Opinion in Microbiology·T Ferenci
Aug 31, 2002·Biophysical Journal·Radhakrishnan MahadevanFrancis J Doyle
Apr 18, 2003·Journal of Bacteriology·Jennifer L Reed, Bernhard Ø Palsson
Jan 22, 2005·Journal of Bacteriology·Elizabeth L Murray, Tyrrell Conway
Jan 25, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andreas Wagner
Mar 15, 2005·FEBS Letters·Andreas Wagner
Mar 29, 2007·Molecular Systems Biology·Jan IhmelsJonathan S Weissman
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Q K BegZ N Oltvai
Nov 6, 2007·Biophysical Journal·R Mahadevan, D R Lovley
Nov 21, 2007·Journal of Theoretical Biology·Jörn BehreStefan Schuster
Jan 25, 2008·BMC Systems Biology·Alexei VazquezZoltán N Oltvai
Feb 6, 2008·Journal of Theoretical Biology·Stefan SchusterDavid A Fell
Mar 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andreas Wagner
Jan 1, 1985·Biotechnology and Bioengineering·P DhurjatiG T Tsao
Jun 20, 2008·BMC Systems Biology·David DeutscherEytan Ruppin
Aug 5, 2008·Nature Methods·Gareth ButlandAndrew Emili
Sep 25, 2008·The American Naturalist·P Chesson, N Huntly
Sep 30, 2008·Biophysical Journal·Linh M TranJames C Liao
Nov 19, 2008·Applied Microbiology and Biotechnology·Cong T TrinhFriedrich Srienc
Apr 8, 2009·Annals of the New York Academy of Sciences·Sabrina Hoffmann, Hermann-Georg Holzhütter
Jun 6, 2009·HFSP Journal·Balázs PappRichard A Notebaart
Jun 30, 2009·Nature Chemical Biology·Bryson D BennettJoshua D Rabinowitz
Aug 4, 2009·Metabolic Engineering·Adam L MeadowsBrad Snedecor
Aug 20, 2009·Molecular Systems Biology·Patrick F SuthersCostas D Maranas
Nov 6, 2009·Molecular Systems Biology·Douwe MolenaarBas Teusink
Jan 23, 2010·Science·Michael CostanzoCharles Boone
Jan 30, 2010·BMC Systems Biology·Kieran SmallbonePedro Mendes
Mar 17, 2010·Applied Microbiology and Biotechnology·Lars M Blank, Lars Kuepfer

❮ Previous
Next ❯

Citations

Apr 12, 2013·Biofouling·M C Ammons, V Copié
Feb 19, 2016·Extremophiles : Life Under Extreme Conditions·Ross P CarlsonBrent M Peyton
Mar 12, 2016·The ISME Journal·Stephen R LindemannAlexander S Beliaev
Oct 22, 2011·Journal of Biotechnology·Hans C BernsteinRoss P Carlson
May 14, 2016·ACS Synthetic Biology·Spencer R Scott, Jeff Hasty
May 20, 2014·Journal of Bacteriology·James Patrick FolsomRoss P Carlson
Nov 27, 2019·Cellular and Molecular Life Sciences : CMLS·Heejoon ParkRoss P Carlson
May 10, 2019·NPJ Systems Biology and Applications·Matteo MoriAndrea De Martino
Jan 11, 2020·Frontiers in Microbiology·Kelly I Ramin, Steven D Allison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.