Abstract
Several loci conferring insecticide resistance in the yellow fever mosquito (Aedes aegypti) have previously been mapped by simple recombinational mapping. Here we describe correlation of these resistance phenotypes with molecular gene probes for insecticide target sites by RFLP mapping. The para sodium channel gene homologue and the GABA receptor gene Resistance to dieldrin map to the same genome regions as the DDT/pyrethroid and cyclodiene resistance loci, respectively. Although the acetylcholinesterase (target site of organophosphorus and carbamate insecticides) gene Ace does not map to any known resistance locus, it maps very close to the sex-determining locus. We discuss the possibilities that, if identified, Ace-mediated resistance in A. aegypti will be sex linked or that, as suggested for anopheline mosquitoes, two independent Ace loci may exist, one of which is autosomal. These results support the importance of target site insensitivity as an insecticide resistance mechanism in mosquitoes.
Citations
Jan 11, 2000·Veterinary Parasitology·D T PassosL S Ozaki
May 30, 2001·Insect Biochemistry and Molecular Biology·Z ChenP Batterham
Jul 5, 2001·Insect Molecular Biology·A MoriD W Severson
Oct 25, 2002·Proceedings. Biological Sciences·Mylène WeillMichel Raymond
Feb 18, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R H ffrench-ConstantN Anthony
Feb 18, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J A McKenzie, P Batterham
Apr 13, 2000·Annual Review of Entomology·J Hemingway, H Ranson
Aug 30, 2008·Genetics·Karla Saavedra-RodriguezWilliam C Black
Jun 7, 2007·Insect Biochemistry and Molecular Biology·Akio MoriDavid W Severson
Jul 16, 2010·Medical and Veterinary Entomology·C SolianiC N Gardenal
Oct 21, 2015·PloS One·Feifei ZouGuiyun Yan
Dec 9, 2000·Annual Review of Entomology·D W SeversonD L Knudson
Oct 5, 2001·Medical and Veterinary Entomology·Y K ChungR Yatiman
Feb 21, 2002·Pest Management Science·Sujin Park, Thomas M Brown
Jul 30, 2002·Insect Molecular Biology·D W SeversonI Morlais
Nov 8, 2018·BioMed Research International·Mariana Rocha DavidRafael Maciel-de-Freitas
Mar 20, 1998·Genetics·G YanD W Severson