Molecular mapping of insecticide resistance genes in the yellow fever mosquito (Aedes aegypti)

The Journal of Heredity
D W SeversonR H ffrench-Constant

Abstract

Several loci conferring insecticide resistance in the yellow fever mosquito (Aedes aegypti) have previously been mapped by simple recombinational mapping. Here we describe correlation of these resistance phenotypes with molecular gene probes for insecticide target sites by RFLP mapping. The para sodium channel gene homologue and the GABA receptor gene Resistance to dieldrin map to the same genome regions as the DDT/pyrethroid and cyclodiene resistance loci, respectively. Although the acetylcholinesterase (target site of organophosphorus and carbamate insecticides) gene Ace does not map to any known resistance locus, it maps very close to the sex-determining locus. We discuss the possibilities that, if identified, Ace-mediated resistance in A. aegypti will be sex linked or that, as suggested for anopheline mosquitoes, two independent Ace loci may exist, one of which is autosomal. These results support the importance of target site insensitivity as an insecticide resistance mechanism in mosquitoes.

Citations

May 30, 2001·Insect Biochemistry and Molecular Biology·Z ChenP Batterham
Feb 18, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R H ffrench-ConstantN Anthony
Feb 18, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J A McKenzie, P Batterham
Apr 13, 2000·Annual Review of Entomology·J Hemingway, H Ranson
Dec 9, 2000·Annual Review of Entomology·D W SeversonD L Knudson
Feb 21, 2002·Pest Management Science·Sujin Park, Thomas M Brown
Nov 8, 2018·BioMed Research International·Mariana Rocha DavidRafael Maciel-de-Freitas

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