Abstract
The goal was to investigate the prognostic value of various molecular markers like CEA, Cyclin D1, Bcl-2, c-Myc, p53, p21ras, Ki-67, CD44, Factor VIII-related antigen, cytokeratin-19, adenoma antigen, and prolactin in patients with Dukes B and Dukes C colorectal adenocarcinoma. These molecular markers were localized immunohistochemically in nonmalignant (n = 36) and malignant (n = 98) diseases of the colorectum. Data were analyzed statistically using the SPSS software program. The patients with colorectal cancer were followed for a period of five years or their death within that period. The expression of carcinoembryonic antigen, Cyclin D1, Bcl-2, CD44, cytokeratin-19 and prolactin was significantly higher in malignant diseases (P < 0.05), whereas, p21ras was found to be significantly higher in nonmalignant diseases (P = 0.002) as compared with their respective counterparts. Besides Dukes stage, multivariate analysis indicated a significantly reduced relapse-free survival in patients expressing CD44 and cytokeratin-19 (P < 0.005). Similarly, besides Dukes stage, multivariate analysis indicated a significantly poor overall survival in patients expressing CD44, cytokeratin-19 and prolactin (P < 0.01). In patients with Dukes B dis...Continue Reading
References
Sep 1, 1992·Scandinavian Journal of Gastroenterology·M TobiS Fligiel
Nov 1, 1992·British Journal of Cancer·J M BhatavdekarD B Balar
Oct 30, 1992·Cancer Letters·M TobiG Luk
Nov 1, 1992·Endocrinology·W J DeVitoC I Ace
Apr 5, 1991·Cell·U GünthertP Herrlich
Jun 1, 1991·Cancer Metastasis Reviews·I R HartJ F Marshall
May 1, 1991·The Journal of Clinical Investigation·S JalkanenP Klemi
Mar 24, 1989·Cell·I StamenkovicB Seed
Nov 1, 1982·Cell·R MollR Krepler
Feb 1, 1994·Cancer·J K GreensonE W Martin
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M AbbasiR H Begent
Feb 1, 1994·Cancer·D D PatelC R Trivedi
Jan 1, 1993·The Journal of Cell Biology·K H HeiderS T Pals
May 1, 1993·Immunology Today·R HoogheE L Hooghe-Peters
Nov 1, 1996·Annals of Surgical Oncology·J L YangP J Crowe
Oct 1, 1996·The Journal of Pathology·J E SmithsonD P Jewell
Jul 1, 1997·Diseases of the Colon and Rectum·J M BhatavdekarD B Balar
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·M G DenisP Lustenberger
Oct 1, 1998·Annals of Surgical Oncology·J M BhatavdekarT P Suthar
Jan 15, 1999·British Journal of Cancer·H L McLeod, G I Murray
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M IlyasW F Bodmer
Jan 24, 2002·Diseases of the Colon and Rectum·J M BhatavdekarT I Trivedi
Sep 1, 1958·British Journal of Cancer·C E DUKES, H J BUSSEY
Apr 1, 1992·Trends in Endocrinology and Metabolism : TEM·S HandwergerE Markoff
Citations
Feb 18, 2006·International Journal of Colorectal Disease·Patricia GrabowskiHans Scherübl
Sep 21, 2004·Virchows Archiv : an International Journal of Pathology·Cord LangnerRichard Zigeuner
Apr 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M C SmithaC Orlando
May 11, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lars HarbaumCord Langner
Aug 31, 2004·Japanese Journal of Clinical Oncology·Luis F Oñate-OcañaDolores Gallardo-Rincón
Dec 4, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Richa JainRunjan Chetty
Apr 29, 2008·Annals of Surgery·Roland S CronerBerthold Lausen
Jan 16, 2009·International Journal of Clinical Practice·E Ioachim
Jun 25, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shuji OginoCharles S Fuchs
Sep 15, 2005·Onkologie·Patricia GrabowskiHans Scherübl
Dec 16, 2010·Radiation Oncology·Ji ZhuZhen Zhang
Apr 15, 2014·PloS One·Yang LiTiangeng You
Dec 5, 2006·Acta chirurgica Iugoslavica·Dino TarabarRadoje Doder
Apr 2, 2011·World Journal of Gastroenterology : WJG·Hua-Bang ZhouHe-Ping Hu
Sep 7, 2005·Pharmacogenomics·Wendy L Allen, Patrick G Johnston
Sep 25, 2012·Digestive Diseases and Sciences·Martin TobiSuzanne Fligiel
Dec 6, 2006·American Journal of Clinical Pathology·Luigi TornilloLuigi Terracciano
Jul 16, 2008·The Journal of Surgical Research·Gregory SergeantBaki Topal
Jul 21, 2009·Histopathology·Runjan ChettyAnita Iyer
Apr 20, 2007·Journal of Surgical Oncology·Chew Yee NganMorito Monden
Mar 12, 2013·Gastroenterology Research and Practice·Jayson WangMona El-Bahrawy
Apr 5, 2012·Ultrastructural Pathology·Ola M Omran, Mostafa Thabet
Apr 24, 2002·Best Practice & Research. Clinical Gastroenterology·Boris PascheAl B Benson
Jul 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy L Allen, Patrick G Johnston
Jan 1, 2011·Cancers·Martin KruschewskiSefer Elezkurtaj
Nov 2, 2013·Biomarkers in Cancer·Eliane C M ZeestratenPeter J K Kuppen
May 19, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jose M Fernández-CebriánBeatriz Fernández-Escudero
Mar 22, 2014·Molecular and Clinical Oncology·Yoshitake UedaSeigo Kitano
Dec 16, 2019·Gene·Maryam Moradi BinabajSeyed Mahdi Hassanian
Sep 24, 2004·The British Journal of Surgery·S AnwarG L Carlson
Jun 9, 2021·Human Pathology·Anne MenzChristian Bernreuther