Molecular markers implicating early malignant events in cervical carcinogenesis

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Hanna-Mari KoskimaaStina Syrjänen

Abstract

Human papillomavirus can induce a stepwise progression of precursor lesions to carcinoma. Sensitive and specific molecular markers are needed to identify the cervical lesions (CIN) at risk for this progression. hTERT activation could be one indicator of a point of no return in malignant progression. The UT-DEC-1 cell line is an in vitro model for the study of human papillomavirus-induced progression. Using molecular mining, nine potential genes interlinking hTERT and viral oncogene expression with the phenotypical features of CIN2 were identified. After preliminary testing with real-time PCR, five genes were selected for further analysis: hTERT, DKC1, Bcl-2, S100A8, and S100A9. These proteins were also tested in a series of 120 CIN lesions using immunohistochemistry. Analysis of the mRNA expression of these genes at different cell passages revealed three time points with significant changes. hTERT, Bcl-2, and S100A9 were also overexpressed in CIN lesions, and the expression pattern changed during the progression toward CIN3 lesions. These identified time points that were combined with the mRNA overexpression of target genes matched events previously shown to be important in the progression toward malignancy: (a) the viral integ...Continue Reading

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Citations

Jul 13, 2012·Head and Neck Pathology·Jaana Rautava, Stina Syrjänen
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Aug 23, 2011·International Journal of Cancer. Journal International Du Cancer·Xin ZhangZhaogang Dong
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Apr 26, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marina MerneStina Syrjänen
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May 24, 2011·American Journal of Obstetrics and Gynecology·Daniela UlrichOlaf Reich
Sep 5, 2018·European Journal of Oral Sciences·Stina Syrjänen

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