Abstract
Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a potential malaria control strategy. There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the potential contribution of IPTi to increases in resistance. We compared the frequency of clinical episodes of malaria caused by P. falciparum parasites with mutations in dhfr and dhps among sick children who received SP or placebo in the context of a randomized, double-blind, placebo-controlled IPTi trial in Mozambique. Half of the children who received placebo harbored quintuple-pure mutant parasites. Nevertheless, the protective efficacy of IPTi within the 35 days after the third dose was 70.8% (95% confidence interval [CI], 40.7%-85.6%). Between month 2 after the third IPTi dose and the end of the follow-up period, children receiving SP harbored more dhps codon 437 mixed infections (odds ratio [OR], 10.56 [95% CI, 1.30-86.14]) and fewer dhps double-pure mutant parasites (OR, 0.43 [95% CI, 0.22-0.84]) than did placebo recipients. IPTi appears to be associated with some changes in the prevalence of genotypes involved in SP resistance. In the face of a high prevalence of quintupl...Continue Reading
References
May 17, 1990·Nature·S J FooteA F Cowman
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D S PetersonT E Wellems
Oct 29, 1994·Lancet·P L AlonsoC Menendez
Jan 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·W M Watkins, M Mosobo
Nov 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·F RobertO Mercereau-Puijalon
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·T TrigliaA F Cowman
Dec 10, 1997·Tropical Medicine & International Health : TM & IH·T JelinekD C Warhurst
Dec 12, 1997·The Journal of Infectious Diseases·C V PloweO K Doumbo
Jun 10, 1998·Lancet·J G KublinC V Plowe
Jul 31, 1998·Annals of Tropical Medicine and Parasitology·N J White
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·M TannerT Smith
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SmithH P Beck
Mar 18, 2000·Antimicrobial Agents and Chemotherapy·A M NzilaW M Watkins
Jul 29, 2000·The Journal of Infectious Diseases·L K BascoP Ringwald
Oct 24, 2000·Tropical Medicine & International Health : TM & IH·P RingwaldL K Basco
Feb 15, 2001·The New England Journal of Medicine·A DjimdéC V Plowe
May 30, 2001·Lancet·D SchellenbergP Alonso
Aug 9, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·S A OmarD C Warhurst
Nov 13, 2002·Experimental Parasitology·Edward K MberuCarol Hopkins Sibley
Jun 14, 2003·The Journal of Antimicrobial Chemotherapy·Agnès AubouyPhilippe Deloron
Apr 27, 2005·Lancet·David SchellenbergPedro Alonso
Sep 2, 2005·Tropical Medicine & International Health : TM & IH·Andrea EganUNKNOWN IPTi Consortium
Oct 1, 2005·BMJ : British Medical Journal·Daniel ChandramohanBrian Greenwood
Nov 4, 2005·The Journal of Infectious Diseases·Florian MarksJurgen May
Mar 1, 2006·Lancet·Badara CisséJean-François Trape
Apr 1, 2006·PLoS Medicine·Wendy Prudhomme O'MearaF Ellis McKenzie
Jul 11, 2006·The Journal of Infectious Diseases·Eusebio MaceteClara Menendez
Jan 24, 2007·Malaria Journal·Neal AlexanderDavid Schellenberg
Citations
Aug 21, 2013·Trends in Parasitology·Meera VenkatesanChristopher V Plowe
Dec 12, 2012·The Journal of Infectious Diseases·Richard J PearceDavid Schellenberg
Feb 4, 2011·Malaria Journal·Filomeno FortesDinora Lopes
Jan 3, 2012·Malaria Journal·Joanna R M Armstrong SchellenbergDavid M Schellenberg
Nov 19, 2008·Malaria Journal·Paula FigueiredoFátima Nogueira
Jan 13, 2010·Malaria Journal·Alassane DickoOgobara K Doumbo
Apr 6, 2012·PLoS Medicine·Nicolas SennIvo Mueller
Sep 15, 2010·PloS One·Jamie T GriffinRoly D Gosling
Apr 17, 2013·The American Journal of Tropical Medicine and Hygiene·Magatte NdiayeMichael Alifrangis
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clara MenéndezAlfredo Mayor
Jan 6, 2011·Parasitology Research·Babacar FayeOumar Gaye
Aug 7, 2013·Comptes rendus biologies·Magatte NdiayeOumar Gaye
Jun 30, 2009·Tropical Medicine & International Health : TM & IH·R D GoslingD Chandramohan
Jun 17, 2015·The Journal of Antimicrobial Chemotherapy·Pamela ChauvinAntoine Berry
Jul 11, 2012·Expert Opinion on Pharmacotherapy·Azucena BardajíClara Menéndez
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Sumadhya Deepika FernandoSenaka Rajapakse
Nov 6, 2008·International Journal for Parasitology·Hans-Peter BeckWillie Weir
Nov 8, 2012·Acta Tropica·Rashad Abdul-GhaniAmal F Allam
Aug 27, 2014·Antimicrobial Agents and Chemotherapy·Celine BarnadasIvo Mueller
Nov 5, 2019·The Journal of Infectious Diseases·Silvie HuijbenAlfredo Mayor
Jul 13, 2021·Frontiers in Genetics·Alexandra T RouxMoses Okpeku