Molecular Markers with Predictive and Prognostic Relevance in Lung Cancer

Lung Cancer International
Alphy Rose-James, Sreelekha Tt

Abstract

Lung cancer accounts for the majority of cancer-related deaths worldwide of which non-small-cell lung carcinoma alone takes a toll of around 85%. Platinum-based therapy is the stronghold for lung cancer at present. The discovery of various molecular alterations that underlie lung cancer has contributed to the development of specifically targeted therapies employing specific mutation inhibitors. Targeted chemotherapy based on molecular profiling has shown great promise in lung cancer treatment. Various molecular markers with predictive and prognostic significance in lung cancer have evolved as a result of advanced research. Testing of EGFR and Kras mutations is now a common practice among community oncologists, and more recently, ALK rearrangements have been added to this group. This paper discusses various predictive and prognostic markers that are being investigated and have shown significant relevance which can be exploited for targeted treatment in lung cancer.

References

Jan 1, 1992·Genes, Chromosomes & Cancer·C Caron de Fromentel, T Soussi
Jul 1, 1995·Nature Medicine·R LubinT Soussi
Jul 19, 1995·Journal of the National Cancer Institute·N E MillsD R Jacobson
May 4, 1994·Journal of the National Cancer Institute·H J XuW F Benedict
Mar 30, 1999·The Journal of Thoracic and Cardiovascular Surgery·T A D'AmicoD H Harpole
Aug 17, 2000·Journal of the National Cancer Institute·T P DangD P Carbone
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Dec 10, 2002·Annual Review of Medicine·Yoshitaka SekidoJohn D Minna
Apr 11, 2003·Oncogene·Ashish GautamGerold Bepler
Apr 25, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Wei-Min GaoPhouthone Keohavong
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rafael RosellUNKNOWN Spanish Lung Cancer Group
Sep 1, 2005·Immunology Letters·George Klein, Eva Klein
Sep 6, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Carlos CampsRafael Rosell
Sep 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F M WachtersH J M Groen
Dec 27, 2005·The Journal of Surgical Research·Hidefumi SasakiYoshitaka Fujii
Jan 7, 2006·Cancer Research·Monica Kong-BeltranRobert Yauch
Jan 20, 2006·British Journal of Cancer·S ForbesM R Stratton
Aug 26, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Osamu KawanoYoshitaka Fujii
Sep 8, 2006·The New England Journal of Medicine·Ken A OlaussenUNKNOWN IALT Bio Investigators
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerold BeplerGeorge Simon
Sep 22, 2006·International Journal of Cancer. Journal International Du Cancer·Fiamma ButtittaAntonio Marchetti
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pascal SèveTony Reiman
Feb 23, 2007·The New England Journal of Medicine·Zhong ZhengGerold Bepler
Aug 19, 2007·The EMBO Journal·Osamu IchikawaIchio Shimada
Nov 8, 2007·PloS One·Rafael RosellJacek Jassem
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ming-Sound TsaoFrances A Shepherd
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James BeanWilliam Pao
May 28, 2008·Oncogene·F E BleekerA Bardelli
Jul 16, 2008·Current Opinion in Pharmacology·Mitch RaponiNicholas C Dracopoli
Dec 20, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Takayuki KosakaTetsuya Mitsudomi

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Citations

Sep 11, 2014·World Journal of Gastroenterology : WJG·Danilo do Rosário PinheiroBárbara do Nascimento Borges
Aug 25, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ozgur TanriverdiArife Zeybek
Nov 29, 2015·Technology in Cancer Research & Treatment·Zhong-Yang WangGregor P C Drummen
Nov 29, 2017·Radiology Research and Practice·Priya Bhattacharji, William Moore
Aug 6, 2015·Cancer Informatics·Hongxiang FengDeruo Liu
Sep 21, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Namita MahadikRajkumar Banerjee

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Methods Mentioned

BETA
lavage
GTPase
xenografts
PCR

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