Molecular mechanism of curcumin action in signaling pathways: Review of the latest research

Phytotherapy Research : PTR
Przemysław LiczbińskiBożena Bukowska

Abstract

Recently, many studies have been conducted trying to explain the molecular mechanism of curcumin action in various pathological states of the cell and the organism. Curcumin is considered to play a role in the regulation of T-lymphocytes function in the lymphoid tissue of the large intestine, apoptosis of the human papilloma and the activity of the 26S proteasome, and p53 level. Research works have shown that curcumin in tumor can regulate reactive oxygen species (ROS) and cytosolic calcium ion level as well as affect other signaling molecules [nuclear factor kappa B (NF-KB), cytokines] triggering endoplasmic reticulum and mitochondrial stress, and thus contributing to death of cancer cells. Curcumin can also arrest of the cell cycle in the G2/M phase leading to apoptosis and/or reduction in cancer cells proliferation. Moreover, curcumin is capable of crossing the blood-brain barrier, and thus it may protect the neurons from oxidative stress and inflammation. Finally, curcumin may play a role in cardiological protection and it is possible to use it in the protection of liver and spleen against oxidative and inflammatory injury. Among signaling pathways regulated by curcumin, the most important seem to be those related with regu...Continue Reading

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Citations

Oct 7, 2020·Microorganisms·Morgan R Jennings, Robin J Parks
Nov 19, 2020·Phytotherapy Research : PTR·Weilong TangHan Jiang
Jan 8, 2021·BMC Complementary Medicine and Therapies·Wei LiMingjiong Ling
Mar 27, 2021·Frontiers in Oncology·Alicia S OmbredaneGraziella A Joanitti
Jun 8, 2021·Experimental Gerontology·Chenmala KarthikaMd Habibur Rahman
Jul 2, 2021·Frontiers in Pharmacology·Cheng YangJianwen Liao
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MiklášováJán Mojžiš
Sep 1, 2020·Journal of Agricultural and Food Chemistry·Jieyuan WuShuang-Yan Tang
Oct 26, 2021·Frontiers in Oncology·Vivek Kumar SoniNaveen Kumar Vishvakarma

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