Molecular mechanism of force generation by dynein, a molecular motor belonging to the AAA+ family

Biochemical Society Transactions
Naoki NumataKazuo Sutoh

Abstract

Dynein is an AAA+ (ATPase associated with various cellular activities)-type motor complex that utilizes ATP hydrolysis to actively drive microtubule sliding. The dynein heavy chain (molecular mass >500 kDa) contains six tandemly linked AAA+ modules and exhibits full motor activities. Detailed molecular dissection of this motor with unique architecture was hampered by the lack of an expression system for the recombinant heavy chain, as a result of its large size. However, the recent success of recombinant protein expression with full motor activities has provided a method for advances in structure-function studies in order to elucidate the molecular mechanism of force generation.

References

Jul 16, 1996·Biochemistry·G Mocz, I R Gibbons
Aug 8, 1997·The Journal of Biological Chemistry·M P Koonce
May 5, 1998·Journal of Molecular Biology·M SamsóM P Koonce
Feb 26, 2000·Molecular Biology of the Cell·M P Koonce, I Tikhonenko
Jul 13, 2000·The Journal of Cell Biology·R D Vale
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·T Yanagida, A H Iwane
Dec 29, 2000·Cell Structure and Function·T Yagi
Jul 28, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T Ogura, A J Wilkinson
Dec 18, 2001·Cell Motility and the Cytoskeleton·K Shiroguchi, Y Y Toyoshima
Apr 23, 2002·Protein Science : a Publication of the Protein Society·Stephen J KingTrina A Schroer
Mar 1, 2003·Nature·Stan A BurgessKazuhiro Oiwa
Feb 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Samara L Reck-Peterson, Ronald D Vale
Feb 13, 2004·Nature·Roop MallikSteven P Gross
May 10, 2005·Nature Structural & Molecular Biology·Takahide KonKazuo Sutoh
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shiori TobaHideo Higuchi
Jul 29, 2006·Cell·Samara L Reck-PetersonRonald D Vale
Nov 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tomohiro ShimaKazuo Sutoh

❮ Previous
Next ❯

Citations

Oct 24, 2008·Nature Reviews. Molecular Cell Biology·Rong Li, Gregg G Gundersen
May 24, 2011·Nature Structural & Molecular Biology·Takahide KonGenji Kurisu
Jun 7, 2011·Nature Structural & Molecular Biology·Neil Billington, James R Sellers
Jan 22, 2009·The Journal of Chemical Physics·Denis TsygankovTimothy C Elston
Dec 6, 2012·The Journal of Biological Chemistry·Rongde QiuXin Xiang
Feb 1, 2012·The Journal of General Physiology·John H LewisYale E Goldman
Mar 25, 2010·Biochemistry. Biokhimii︠a︡·A Yu Lomakin, E S Nadezhdina
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Murat BalabanBirgitta Henriques-Normark
Jun 12, 2013·The FEBS Journal·Maorong Wen, Chunguang Wang
Apr 1, 2008·Biophysical Journal·Kathleen A LesichCharles B Lindemann
Nov 29, 2014·Cytoskeleton·Charles B LindemannKathleen A Lesich
Feb 11, 2009·Cell·Anthony J RobertsStan A Burgess
Nov 26, 2016·Physical Chemistry Chemical Physics : PCCP·Mandira Dutta, Biman Jana
Jan 22, 2010·Nature·T J Mitchison, H M Mitchison
Jan 23, 2008·Biochemical Society Transactions·Andreas FörsterR John Mayer
Feb 11, 2010·Journal of Cell Science·Charles B Lindemann, Kathleen A Lesich
Dec 17, 2008·Science·Linda A Amos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Andrew P Carter, Ronald D Vale
Current Opinion in Structural Biology
Stan A Burgess, P J Knight
© 2021 Meta ULC. All rights reserved