PMID: 21554201May 11, 2011Paper

Molecular mechanism of liver cancer

Anti-cancer Agents in Medicinal Chemistry
Hongming PanWendong Huang

Abstract

Liver cancer, hepatocellular carcinoma (HCC) in particular, is one of the most deadly cancers worldwide, and the incidence of HCC is increasing rapidly in the United States and other developed countries. Epidemiological studies have identified major risk factors for HCC, including infection with hepatitis B and C virus (HBV and HCV), exposure to certain chemicals, high intake of alcohol, as well as metabolic diseases such as obesity and diabetes that are rapidly rising in the US. Although the etiologies for liver carcinogenesis are relatively well defined, the exact mechanism and pathways leading to cancer development are still unclear. Chronic liver injury, followed by inflammation and irregular liver regeneration has been suggested as an important step in hepatocarcinogenesis. Therefore, the identification of key factors that protect the liver from injury and inflammation could provide valuable insight into the development of HCC. In this review, we will summarize the recent findings in HCC studies, mainly focusing on the new molecular link among inflammation, liver repair and HCC.

Citations

Oct 3, 2013·Critical Reviews in Toxicology·Melvin E AndersenJacqueline Patterson
Jun 18, 2017·Biochemical and Biophysical Research Communications·Zhikuan HeXuequn Ren
Sep 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lei WangAn-Gang Yang
Oct 28, 2018·Molecular Biology Reports·Farzaneh RaeisiAsghar Arshi
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Abdul Hadi AzlinPhaik Leng Cheah
Aug 28, 2019·Medicina·Ali AlqahtaniDanae M Hammouda
Apr 11, 2020·Hepatic Oncology·Justin Jit Hin TangTan Boon Toh
Feb 2, 2013·Digestive Diseases and Sciences·Mutsumi TsuchishimaMikihiro Tsutsumi
Feb 19, 2021·Frontiers in Cell and Developmental Biology·Zhen Long NgQiang Wu

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