PMID: 2498486Apr 1, 1989Paper

Molecular mechanism of naproxen photosensitization in red blood cells

Journal of Photochemistry and Photobiology. B, Biology
L L CostanzoM Fama

Abstract

Red blood cell lysis photosensitized by naproxen was investigated. The photohemolysis rate was enhanced by deuterium oxide and inhibited by butylated hydroxyanisole, reduced glutathione, sodium azide and superoxide dismutase. Photohemolysis was also observed under anaerobic conditions. In the absence of red cells the irradiation of deaerated solutions underwent a decarboxylation process via intermediate radicals, while under aerobic conditions photo-oxidation leading to the photoproduct 6-methoxy-2-acetonaphthone occurred. A molecular mechanism involving free radicals and singlet oxygen as important intermediates and consistent with the overall results is proposed.

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Citations

Jul 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M A MirandaL A Martinez
Aug 1, 1991·Journal of Photochemistry and Photobiology. B, Biology·G De GuidiM Cambria Famá
Apr 15, 1992·Journal of Photochemistry and Photobiology. B, Biology·J V CastellI M Morera
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Jan 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·F VargasI López
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Apr 6, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ozlem Oğün Cirli, Vasif Hasirci
Dec 30, 1998·Journal of Photochemistry and Photobiology. B, Biology·L A MartínezE Oliveros
Sep 1, 1989·Photochemistry and Photobiology·L L CostanzoM Fama
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