Molecular mechanism of regulation of the calcium-binding protein calbindin-D9k, and its physiological role(s) in mammals: a review of current research

Journal of Cellular and Molecular Medicine
Kyung-Chul Choi, Eui-Bae Jeung

Abstract

Calbindin-D(9k) (CaBP-9k) is a cytosolic calcium-binding protein that is expressed in a variety of tissues, such as uterus, placenta, intestine, kidney, pituitary gland and bone. At present, the precise role(s) of CaBP-9k remains to be clarified. CaBP-9k-null mice are normal, which indicates that other calcium-transporter genes can compensate for the lack CaBP-9k. Uterine CaBP-9k has been shown to be involved in the regulation of myometrial activity by intracellular calcium. In the uterus and placenta, CaBP-9k expression is regulated by the sex steroid hormones oestrogen (E2) and progesterone (P4). Intestinal CaBP-9k is involved in intestinal calcium absorption, and is regulated at the transcriptional and post-transcriptional levels by 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D. Thus, evidence to date suggests that CaBP-9k may be regulated in a tissue-specific manner. In this review, we will summarize current data on the molecular mechanism of regulation of CaBP-9k in mammals, including recent research data generated in our laboratories.

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Citations

Jul 1, 2010·Animal : an International Journal of Animal Bioscience·E E ConnorC Li
Aug 6, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thuy T B Vo, Eui-Bae Jeung
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Jun 13, 2012·International Journal of Environmental Research and Public Health·Eui-Man JungEui-Bae Jeung
Oct 4, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Annekathrin Martina KeilerOliver Zierau
Jun 15, 2016·Journal of Toxicology and Environmental Health. Part a·Vanessa Cristina de Oliveira SouzaFernando Barbosa
Jan 30, 2018·Journal of Cellular Biochemistry·Li-Ping YangQun Zhao
May 29, 2009·American Journal of Physiology. Renal Physiology·Geun-Shik LeeEui-Bae Jeung
Jul 17, 2019·Cold Spring Harbor Perspectives in Biology·Beat Schwaller
Jul 11, 2012·Molecular Reproduction and Development·Hyo-Jin AhnEui-Bae Jeung
Mar 3, 2020·Cell Calcium·Sergei E PermyakovEugene A Permyakov

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Methods Mentioned

BETA
electrophoretic mobility shift assay
transfection

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