PMID: 8452853Mar 14, 1993Paper

Molecular mechanism of the lipid vesicle longevity in vivo

Biochimica Et Biophysica Acta
G Blume, G Cevc

Abstract

An important, if not the chief, condition for the prolongation of the circulation times of lipid vesicles in vivo is the suppression of macromolecular adsorption onto the surface of such vesicles. This adsorption can be prevented very efficiently by a zone of suitably designed and mobile steric hindrances near the lipid layer surface. Lipid vesicles with such a surface coat, cryptosomes, thus circulate in blood for very long periods of time after systemic applications. Lipid vesicles composed of phosphatidylcholine molecules and of suitable polyoxyethylene (PEG) derivatives of phosphatidylethanolamine, for example, remain in the blood circulation 8-10-times longer than standard liposomes made of phosphatidylcholine only: in mice the half-lives of the former and latter vesicles, after an i.v. administration, are approx. 0.6 h and between 5.9 and 13.8 h, respectively. Vesicle longevity is not destroyed by the phosphatidylcholine chains fluidity. Vesicles consisting of a mixture of distearoylphosphatidylethanolamine-PEG (DSPE-PEG) with distearoylphosphatidylcholine or cryptosomes made of DSPE-PEG and soy-bean phosphatidylcholine, consequently, have a very similar fate in vivo. Furthermore, the cryptosome longevity is not affected ...Continue Reading

References

Nov 18, 1991·Biochimica Et Biophysica Acta·D D LasicD Papahadjopoulos
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D PapahadjopoulosC Redemann
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A Gabizon, D Papahadjopoulos

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Citations

Sep 1, 1996·Journal of Molecular Recognition : JMR·V P Torchilin
Jul 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·M J Lawrence
Apr 28, 2004·Advanced Drug Delivery Reviews·Anatoly N Lukyanov, Vladimir P Torchilin
Mar 19, 2013·International Journal of Pharmaceutics·Kacoli Sen, Mahitosh Mandal
Nov 12, 2002·Chemistry and Physics of Lipids·Michael HodeniusHeiko Lueken
Oct 8, 1999·Il Farmaco·F M Veronese, M Morpurgo
Jun 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J LerouxD C Drummond
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·V P Torchilin
Sep 5, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·P ChandaroyS W Hui
Jan 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brian J LestiniRoger E Marchant
Jul 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Peter J PhotosDennis E Discher
Jun 6, 2000·Advanced Drug Delivery Reviews·M C Woodle
Jul 25, 2003·Biophysical Chemistry·Yan jun WangRonald J Clarke
Jul 25, 2003·International Journal of Pharmaceutics·Jeffrey WellsSek Wen Hui
Jun 11, 1999·International Journal of Pharmaceutics·K JørgensenC Vermehren
Jun 11, 1999·International Journal of Pharmaceutics·C VermehrenS Frokjaer
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·M M GasparM E Cruz
Oct 12, 2010·Journal of Angiogenesis Research·Ariel Gilert, Marcelle Machluf
Mar 15, 2012·The AAPS Journal·Rupa R Sawant, Vladimir P Torchilin
Sep 9, 2010·Biological & Pharmaceutical Bulletin·Atsuko HiokiYoshie Maitani
Nov 6, 2003·Chemical & Pharmaceutical Bulletin·Toshihito HosokawaEiji Hayakawa
Aug 28, 2012·International Journal of Nanomedicine·Lulu CaiLijuan Chen
Aug 14, 2012·International Journal of Nanomedicine·Kazuo WatanabeYoshie Maitani
Oct 15, 2013·International Journal of Nanomedicine·Christopher G EnglandHermann B Frieboes
Sep 13, 2011·Journal of Experimental Stroke & Translational Medicine·Shimin LiuH Richard Winn
Aug 14, 2012·ISRN Pharmaceutics·Dinesh KumarMahendra Singh Rathore
Mar 7, 2014·Trends in Molecular Medicine·Maximilian SchienerOliver Soehnlein
Sep 25, 2014·BioMed Research International·Shyamal Kumar KunduChiranjib Chakraborty
Jan 10, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Swati BiswasBalaram Ghosh
Feb 3, 2016·Critical Reviews in Oncology/hematology·Peter AlexanderTimothy S Pardee
Jul 18, 2015·Biochemical and Biophysical Research Communications·Janos Szebeni, Gert Storm
May 11, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Joanna RossiJean-Christophe Leroux
Apr 14, 2007·The Journal of Pharmacy and Pharmacology·H Karanth, R S R Murthy
Jan 25, 2003·Biochimica Et Biophysica Acta·M M GasparM E M Cruz

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