Molecular mechanism on cadmium-induced activity changes of catalase and superoxide dismutase

International Journal of Biological Macromolecules
Jing WangYadong Chen

Abstract

Cadmium contributes to adverse effects of organisms probably because of its ability to induce oxidative stress via alterations in activities of antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD), but their molecular mechanisms remain unclear. We investigated the molecular mechanism of CAT and SOD response under Cd-induced oxidative stress in the liver of zebrafish. The enzyme activity changes observed in vitro were consistent with those seen in vivo, indicating the direct interaction of CAT and SOD with Cd contributes to their activity change in vivo. Further experiments utilizing multiple spectroscopic methods, isothermal titration calorimetry and a molecular docking study were performed to explore the mechanism of molecular interaction of CAT and SOD with Cd. Different interaction patterns were found that resulted in misfolding and changed the enzyme activities. Taken together, we suggest the misfolding of CAT and SOD contributes to their activity change under Cd-induced oxidative stress in vivo.

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Jan 24, 2016·Environmental Science and Pollution Research International·Xiaomin GongXiaofei Tan
Oct 17, 2015·The International Journal of Biochemistry & Cell Biology·Yijie DongMingchun Li
Apr 19, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mingyang JingRutao Liu
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