Molecular mechanism underlying sialic acid as an essential nutrient for brain development and cognition.

Advances in Nutrition
Bing Wang

Abstract

The early stages of neurodevelopment in infants are crucial for establishing neural structures and synaptic connections that influence brain biochemistry well into adulthood. This postnatal period of rapid neural growth is of critical importance for cell migration, neurite outgrowth, synaptic plasticity, and axon fasciculation. These processes thus place an unusually high demand on the intracellular pool of nutrients and biochemical precursors. Sialic acid (Sia), a family of 9-carbon sugar acids, occurs in large amounts in human milk oligosaccharides and is an essential component of brain gangliosides and sialylated glycoproteins, particularly as precursors for the synthesis of the polysialic acid (polySia) glycan that post-translationally modify the cell membrane-associated neural cell adhesion molecules (NCAM). Human milk is noteworthy in containing exceptionally high levels of Sia-glycoconjugates. The predominate form of Sia in human milk is N-acetylneuraminic acid (Neu5Ac). Infant formula, however, contains low levels of Sia consisting of both Neu5Ac and N-glycolyneuraminic acid (Neu5Gc). Current studies implicate Neu5Gc in several human inflammatory diseases. Polysialylated NCAM and neural gangliosides both play critical r...Continue Reading

References

Jul 1, 1977·Pharmacology, Biochemistry, and Behavior·H E Savaki, G M Levis
Feb 1, 1992·Glycobiology·A Varki
Jan 1, 1990·Annals of the New York Academy of Sciences·B L Morgan
Sep 25, 1989·Biochimica Et Biophysica Acta·L SvennerholmB M Rynmark
Nov 15, 1983·Biochemical and Biophysical Research Communications·R K Margolis, R U Margolis
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·D BarbeauL K Srivastava
Jan 23, 1995·Behavioural Brain Research·H Rahmann
Dec 1, 1995·Biological Chemistry Hoppe-Seyler·R RuedaA Gil
Apr 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·A Sánchez-DíazP Hueso
Dec 6, 1997·Archives of Disease in Childhood·T H TramP McVeagh
Jan 7, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·B GalP Hueso
Oct 24, 1998·American Journal of Physical Anthropology·E A MuchmoreA Varki
Dec 16, 1998·The Journal of Biological Chemistry·B E Close, K J Colley
Sep 29, 1999·The American Journal of Clinical Nutrition·R Uauy, P Peirano
Nov 24, 1999·Acta Paediatrica. Supplement·G V CoppaO Gabrielli
Mar 20, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·B WangP McVeagh
Aug 21, 2001·Nestlé Nutrition Workshop Series. Clinical & Performance Programme·R UauyP Peirano
Sep 22, 2001·The American Journal of Clinical Nutrition·B WangP Petocz
Feb 11, 2003·The Journal of Biological Chemistry·Uichiro YabeKen Kitajima
Oct 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Pam TangvoranuntakulElaine Muchmore
Oct 25, 2003·European Journal of Clinical Nutrition·B Wang, J Brand-Miller
Nov 5, 2003·The American Journal of Clinical Nutrition·Bing WangJennie Brand-Miller
Nov 24, 2004·The Journal of Biological Chemistry·Muriel BardorAjit Varki
Dec 2, 2004·Journal of Pediatric Gastroenterology and Nutrition·Samuel Martín-SosaPablo Hueso
Jan 7, 2005·The New England Journal of Medicine·Neil MarlowUNKNOWN EPICure Study Group
Dec 14, 2005·Journal of Developmental and Behavioral Pediatrics : JDBP·Glen P Aylward
Feb 8, 2007·The American Journal of Clinical Nutrition·Bing WangJennie Brand-Miller
Apr 11, 2007·Molecular and Cellular Biology·Maria HedlundAjit Varki
Dec 7, 2007·Nature Reviews. Neuroscience·Urs Rutishauser

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Citations

Feb 19, 2013·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Haroldo da Silva FerreiraBernardo Lessa Horta
Jun 14, 2014·PloS One·Shirin Macias RostamiSean Austin
May 16, 2012·Advances in Nutrition·Clemens KunzSharon M Donovan
Apr 20, 2014·International Journal of Molecular Sciences·Marko JovanovićJasna Peter-Katalinić
Jul 26, 2014·Analytical and Bioanalytical Chemistry·L Renee RuhaakCarlito B Lebrilla
Oct 14, 2014·BMC Complementary and Alternative Medicine·Mei Yeng YewKhuen Yen Ng
May 27, 2015·Nutrients·Kate PalmanoPaul McJarrow
Jan 26, 2016·Journal of Agricultural and Food Chemistry·Marlon M ReisNicole Roy
Nov 28, 2012·Pediatric Clinics of North America·Olivia Ballard, Ardythe L Morrow
Apr 12, 2016·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Roland Schauer
Jun 27, 2015·Critical Reviews in Food Science and Nutrition·Christoph H RöhrigNigel Baldwin
Apr 18, 2013·Journal of Proteomics·Paola RoncadaMalcolm W Kennedy
Apr 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ran XieXing Chen
May 24, 2016·Nature Genetics·Clara D M van KarnebeekAndrea Superti-Furga
Jun 16, 2016·Frontiers in Microbiology·Gerald W TannockBlair Lawley
Dec 12, 2017·Mass Spectrometry Reviews·Qiwei ZhangJianjun Li
Jul 30, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Esra DemirciSefer Kumandas
Apr 25, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Fatemeh Ramezani Kapourchali, Gail A M Cresci
Feb 13, 2020·The American Journal of Psychiatry·Marieke KleinBarbara Franke
Apr 6, 2020·Glycobiology·Sara PorfirioParastoo Azadi
Apr 25, 2018·Journal of Molecular Recognition : JMR·Rahul MishraHelen Blanchard
May 31, 2019·Advances in Nutrition·Lu ZhengNora Schneider

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