Molecular Mechanism Whereby Maternal Exposure to Dioxin Suppresses Sexual Maturation of the Offspring after Growing Up

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Tomoki Takeda

Abstract

Dioxins, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are responsible for producing serious toxic effects in the next generation, such as sexual immaturity. Our laboratory found that treating pregnant rats on gestational day 15 with TCDD (1 μg/kg orally) targets pituitary luteinizing hormone (LH) to attenuate testicular steroidogenesis in fetuses. Because sex steroids during a short window ("the critical period") in the perinatal stage stimulate brain differentiation closely linked to sexual maturation, it is likely that TCDD imprints sexual immaturity on the offspring due to the lowered expression of LH during the fetal period. To address this hypothesis, we first investigated the effect of supplementation of equine chorionic gonadotropin (eCG), an LH-mimicking hormone, in fetuses exposed to TCDD. The result showed that eCG ameliorated defects in sexual behavior in adulthood as well as in steroidogenesis during the fetal stage. We also found that maternal exposure to TCDD induced the pituitary expression of histone deacetylases (HDACs) in fetuses. In agreement with this, TCDD deacetylated the histones wrapped around the LHβ gene, and valproic acid, an HDAC inhibitor, blocked the reduced level of LHβ caused by TCDD. Th...Continue Reading

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Citations

Jan 16, 2021·International Journal of Molecular Sciences·Masutaka FurueGaku Tsuji

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