Molecular mechanisms and global dynamics of fibrillation: an integrative approach to the underlying basis of vortex-like reentry

Journal of Theoretical Biology
José Jalife, Omer Berenfeld

Abstract

Art Winfree's scientific legacy has been particularly important to our laboratory whose major goal is to understand the mechanisms of ventricular fibrillation (VF). Here, we take an integrative approach to review recent studies on the manner in which nonlinear electrical waves organize to result in VF. We describe the contribution of specific potassium channel proteins and of the myocardial fiber structure to such organization. The discussion centers on data derived from a model of stable VF in the Langendorff-perfused guinea pig heart that demonstrates distinct patterns of organization in the left (LV) and right (RV) ventricles. Analysis of optical mapping data reveals that VF excitation frequencies are distributed throughout the ventricles in clearly demarcated domains. The highest frequency domains are found on the anterior wall of the LV at a location where sustained reentrant activity is present. The optical data suggest that a high frequency rotor that remains stationary in the LV is the mechanism that sustains VF in this model. Computer simulations predict that the inward rectifying potassium current (IK1) is an essential determinant of rotor stability and frequency, and patch-clamp results strongly suggest that the outw...Continue Reading

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Citations

Nov 26, 2010·Cardiovascular Research·José Jalife
Feb 18, 2010·Circulation. Arrhythmia and Electrophysiology·Peng-Sheng ChenShien-Fong Lin
Apr 30, 2014·Revista Española De Cardiología·David Calvo, José Jalife
May 13, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Miguel VaqueroJosé Jalife
Mar 21, 2007·Journal of Cellular and Molecular Medicine·M ManoachT Podzuweit
Aug 2, 2006·Journal of Cardiovascular Electrophysiology·Tsu-Juey WuPeng-Sheng Chen
Sep 15, 2004·Journal of Theoretical Biology·James P Keener
Nov 11, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·José Jalife
Feb 10, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mina AttinSteven M Pogwizd
Apr 28, 2016·Future Cardiology·David E KrummenAmir A Schricker
Jul 21, 2015·BJPsych Bulletin·Penelope Campling
May 3, 2008·Journal of Applied Physiology·Lei LiangYi-Han Chen
Dec 6, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Sami F NoujaimJosé Jalife
Dec 17, 2015·Journal of Physics D: Applied Physics·A RabinovitchO Berenfeld
Feb 6, 2017·Chaos·Hiroshi Ashikaga, Ryan G James
Sep 14, 2019·Progress in Biophysics and Molecular Biology·Claudia Richter, Tobias Bruegmann

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