Molecular mechanisms and therapeutic targets in neuroblastoma

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
John Inge JohnsenMalin Wickström

Abstract

Neuroblastoma is the most common extracranical tumor of childhood and the most deadly tumor of infancy. It is characterized by early age onset and high frequencies of metastatic disease but also the capacity to spontaneously regress. Despite intensive therapy, the survival for patients with high-risk neuroblastoma and those with recurrent or relapsed disease is low. Hence, there is an urgent need to develop new therapies for these patient groups. The molecular pathogenesis based on high-throughput omics technologies of neuroblastoma is beginning to be resolved which have given the opportunity to develop personalized therapies for high-risk patients. Here we discuss the potential of developing targeted therapies against aberrantly expressed molecules detected in sub-populations of neuroblastoma patients and how these selected targets can be drugged in order to overcome treatment resistance, improve survival and quality of life for these patients and also the possibilities to transfer preclinical research into clinical testing.

Citations

Aug 1, 2020·Journal of Cellular Physiology·Taranom MobasheriNima Rezaei
Feb 15, 2019·Frontiers in Molecular Neuroscience·John Inge JohnsenMalin Wickström
Jul 1, 2020·Cancer Immunology, Immunotherapy : CII·Maria V StegantsevaAlexander N Meleshko
May 31, 2020·BMC Cancer·Illya MartynovJoachim Schoenberger
Mar 15, 2019·International Journal of Molecular Sciences·Caroline E Nunes-XavierRafael Pulido
Jan 13, 2019·The Journal of Pharmacology and Experimental Therapeutics·Carlos Rodríguez-NogalesMaría J Blanco-Prieto
Sep 16, 2020·Cancers·Venugopal GundaKishore B Challagundla
Nov 7, 2020·Medicinal Research Reviews·Atif ZafarRuiwen Zhang
May 11, 2021·Frontiers in Cell and Developmental Biology·Aleksandar KrsticDavid J Duffy
Nov 14, 2020·International Immunopharmacology·Jingjing SongLibin Zhu
Nov 5, 2021·PLoS Computational Biology·Mathurin DorelNils Blüthgen

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