Feb 14, 2020

Molecular mechanisms and therapeutic targets of inflammatory-related Cardiovascular diseases: from molecular mechanisms to therapeutic targets

Current Pharmaceutical Design
Celestino SarduRaffaele Marfella

Abstract

Inflammation is a pathogenic response to multiple factors, that cause over activation of different molecules and pro-inflammatory cellular lines. Different behavioral factors and risk factors might enhance the inflammatory stress, and this might cause cardiovascular disease (CVD). CVD is the world's leading cause of morbidity and mortality, and it is represented by hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congenital heart disease and cardiomyopathies. In this context, inflammation is both a cause and an aggravating factor in CVD, as well as a mediator of its worst prognostic. The mechanisms that link inflammation to CVD are multiple, complex and multi-factorial. To date, the role of inflammation in the genesis and progression of CVD has been extensively analyzed in recent studies. However, in last decades new biomarkers are joining the already known inflammatory biomarkers, such as C-reactive protein, interleukins, tumor necrosis factor alpha and nitrotyrosine. Among these new biomarkers we have to report sirtuins, microRNAs, ST2 protein, apolipoprotein E protein, adiponectin and others. These biomarkers are preferentially expressed local...Continue Reading

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Mentioned in this Paper

Prognosis Bad
Peripheral Vascular Diseases
Research
MicroRNAs
FOXD3 gene
Peripheral Blood
Inflammation
Cardiovascular Diseases
Sirtuins
Hypertensive Disease

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