Molecular Mechanisms and Treatment Strategies in Diabetic Nephropathy: New Avenues for Calcium Dobesilate-Free Radical Scavenger and Growth Factor Inhibition

BioMed Research International
Hermann HallerJan Menne

Abstract

Diabetic nephropathy is one of the most important microvascular complications of diabetes mellitus and is responsible for 40-50% of all cases of end stage renal disease. The therapeutic strategies in diabetic nephropathy need to be targeted towards the pathophysiology of the disease. The earlier these therapeutic strategies can bring about positive effects on vascular changes and prevent the vasculature in patients with diabetes from deteriorating, the better the renal function can be preserved. Studies evaluating anti-inflammatory and antioxidative strategies in diabetic nephropathy demonstrate the need and value of these novel treatment avenues. CaD is an established vasoactive and angioprotective drug that has shown a unique, multitarget mode of action in several experimental studies and in different animal models of diabetic microvascular complications. On the molecular level, CaD reduces oxidative stress and inhibits growth factors such as fibroblast growth factor and vascular endothelial growth factors. Recent findings have demonstrated a strong rationale for its use in reducing urine albumin excretion rate and markers of inflammation as well as improving endothelial function. Its beneficial effects make it an attractive ...Continue Reading

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Citations

Mar 8, 2018·In Vitro Cellular & Developmental Biology. Animal·Qun TangChunyan Liu
Feb 9, 2021·Journal of Diabetes and Metabolic Disorders·Mehmet Zahid KocakBetül Alaca
Oct 16, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Gholamreza BazmandeganMorteza Amirteimoury
Sep 23, 2021·International Angiology : a Journal of the International Union of Angiology·Giacomo GastaldiMarie Josee VAN Rijn

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BETA
biopsies
electron microscopy

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