Molecular mechanisms associated with the antidepressant effects of the class I histone deacetylase inhibitor MS-275 in the rat ventrolateral orbital cortex

Brain Research
Huali LinJianguo Shi

Abstract

Histone modifications mediated by histone acetylation are thought to play an important role in the pathogenesis and treatment of depression. Recent studies have revealed that histone deacetylase inhibitors (HDACis), such as sodium valproate (VPA) and MS-275, may be involved in the pathogenesis of depression and in the underpinnings of antidepressant therapeutic action in several brain regions, including the ventrolateral orbital cortex (VLO). In the present study, we investigated whether the class I histone deacetylase inhibitor MS-275 exerts antidepressant-like effects when infused bilaterally into the VLO of a rat, using the forced swimming test (FST) and tail suspension test (TST) as behavioral measures. We found that chronic intra-VLO infusion of MS-275 significantly reduced immobility time in the FST and TST compared with vehicle-treated controls, similar to the effects of systemically administered fluoxetine. These antidepressant-like effects of MS-275 are associated with an increase in H3 acetylation and elevated CREB and BDNF levels in the VLO. Our findings suggest the possibility that alterations in gene expression due to chromatin remodeling, including upregulation of CREB and BDNF, may be involved in the antidepressa...Continue Reading

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Citations

Jul 11, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jin-Fang GeFei-Hu Chen
Mar 31, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Manabu FuchikamiShigeto Yamawaki
Sep 11, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xiaoyan QiuYuemin Li
Nov 24, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Chiara FabbriAlessandro Serretti
Feb 20, 2018·Pharmacological Reports : PR·Paulina MisztakMagdalena Sowa-Kućma
Oct 2, 2019·Current Neuropharmacology·Kaipuzha Venu AthiraSumana Chakravarty
Mar 15, 2019·Molecular Psychiatry·Gopalkumar RakeshSteven T Szabo
May 16, 2019·Neural Regeneration Research·Hae June LeeJoong Sun Kim
Apr 4, 2021·Journal of Personalized Medicine·Piotr CzarnyTomasz Sliwinski
Aug 5, 2017·Journal of Medicinal Chemistry·Erika BourguetMickaël Naassila
Aug 29, 2021·Pharmaceuticals·Marcin JanowskiAleksandra Pękowska

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