Molecular mechanisms by which metabolic control may improve outcomes.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Derek Le Roith

Abstract

To summarize available evidence providing potential explanations for metabolic and nonmetabolic abnormalities during conditions of acute stress and possible mechanisms whereby insulin therapy may affect these changes. Recent studies have demonstrated a remarkable effect of intensive insulin therapy and reductions in morbidity and mortality in patients in intensive-care units and other hospital settings. The mechanisms involved in these effects are under thorough investigation. Insulin therapy improves glucose and lipid homeostasis, both of which are deleterious to the tissues, especially during severe stress. In addition, insulin has direct effects on the levels of inflammatory cytokines and other proteins that may influence the overall outcome of patients undergoing various stressful conditions. Analysis of published studies suggests that the beneficial effects of insulin therapy may be derived from both direct and indirect mechanisms.

References

May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G S HotamisligilB M Spiegelman
Nov 15, 2001·The Journal of Biological Chemistry·Monica MontagnaniBoris Draznin
Jan 17, 2002·The New England Journal of Medicine·G van den BergheR Bouillon
May 22, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Resea
Jun 6, 2003·The New England Journal of Medicine·David M NathanUNKNOWN Epidemiology of Diabetes Interventions and Complications Research Group
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Ahmad Aljada

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Citations

Oct 6, 2004·Current Diabetes Reports·Andrew J Ahmann
Sep 8, 2012·Epilepsy Research and Treatment·Fahd Al Sufiani, Lee Cyn Ang
Mar 2, 2006·Current Cardiology Reports·Valentine Burroughs, Jesse Weinberger
Sep 8, 2012·Epilepsy Research and Treatment·Gustavo SeiferSilvia Kochen
Jan 31, 2007·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Susan S Braithwaite
Nov 23, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jason M Hollander, Jeffrey I Mechanick
Feb 16, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·M Molly McMahon, John M Miles

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