Molecular mechanisms driving homeostatic plasticity of neurotransmitter release

Frontiers in Cellular Neuroscience
Vesna LazarevicAnna Fejtova

Abstract

Homeostatic plasticity is a process by which neurons adapt to the overall network activity to keep their firing rates in a reasonable range. At the cellular level this kind of plasticity comprises modulation of cellular excitability and tuning of synaptic strength. In this review we concentrate on presynaptic homeostatic plasticity controlling the efficacy of neurotransmitter release from presynaptic boutons. While morphological and electrophysiological approaches were successful to describe homeostatic plasticity-induced changes in the presynaptic architecture and function, cellular and molecular mechanisms underlying those modifications remained largely unknown for a long time. We summarize the latest progress made in the understanding of homeostasis-induced regulation of different steps of the synaptic vesicle cycle and the molecular machineries involved in this process. We particularly focus on the role of presynaptic scaffolding proteins, which functionally and spatially organize synaptic vesicle clusters, neurotransmitter release sites and the associated endocytic machinery. These proteins turned out to be major presynaptic substrates for remodeling during homeostatic plasticity. Finally, we discuss cellular processes and...Continue Reading

Citations

Jan 23, 2016·Frontiers in Synaptic Neuroscience·Eckart D GundelfingerCraig C Garner
Oct 21, 2015·Frontiers in Cellular Neuroscience·Jaichandar Subramanian, Dion Dickman
Feb 28, 2015·Experimental Cell Research·Katrin MichelSusanne Schoch
Feb 25, 2015·Nature Neuroscience·Kevin Staley
Nov 12, 2014·Annual Review of Physiology·Graeme W Davis, Martin Müller
Jun 23, 2016·Journal of Neurochemistry·Katarzyna LepetaConstanze Seidenbecher
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Dec 1, 2020·Frontiers in Cellular Neuroscience·Colten K LankfordSheila A Baker
Nov 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mickaël ZbiliDominique Debanne

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Methods Mentioned

BETA
nucleotide exchange
GTPase
ubiquitination

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