Molecular mechanisms for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures

Mutation Research
H NakagamaHirokazu Fukuda

Abstract

Mammalian genomes contain several types of repetitive sequences. Some of these sequences are implicated in various specific cellular events, including meiotic recombination, chromosomal breaks and transcriptional regulation, and also in several human disorders. In this review, we document the formation of DNA secondary structures by the G-rich repetitive sequences that have been found in several minisatellites, telomeres and in various triplet repeats, and report their effects on in vitro DNA synthesis. d(GGCAG) repeats in the mouse minisatellite Pc-1 were demonstrated to form an intra-molecular folded-back quadruplex structure (also called a G4' structure) by NMR and CD spectrum analyses. d(TTAGGG) telomere repeats and d(CGG) triplet repeats were also shown to form G4' and other unspecified higher order structures, respectively. In vitro DNA synthesis was substantially arrested within the repeats, and this could be responsible for the preferential mutability of the G-rich repetitive sequences. Electrophoretic mobility shift assays using NIH3T3 cell extracts revealed heterogeneous nuclear ribonucleoprotein (hnRNP) A1 and A3, which were tightly and specifically bound to d(GGCAG) and d(TTAGGG) repeats with K(d) values in the orde...Continue Reading

References

Jan 1, 1992·Human Mutation·F RousseauJ L Mandel
Aug 11, 1992·Nucleic Acids Research·P BalagurumoorthyV Sasisekharan
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SuganumaT Sugimura
Apr 1, 1987·British Journal of Cancer·S L TheinJ S Wainscoat
Mar 7, 1985·Nature·A J JeffreysS L Thein
Sep 22, 1995·Science·T G Krontiris
Feb 1, 1994·Nature Genetics·A J JeffreysJ A Armour
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Fry, L A Loeb
Aug 19, 1993·The New England Journal of Medicine·T G KrontirisN Risch
May 1, 1993·Nature Genetics·J L Mandel
Sep 1, 1995·Electrophoresis·A J JeffreysD L Neil
Mar 1, 1996·The Journal of Biological Chemistry·R M HowellK Usdin
Dec 6, 1996·Journal of Molecular Biology·P CatastiG Gupta
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·H NakagamaM Nagao
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·H ImaiM Nagao
Apr 4, 1998·Nucleic Acids Research·T SimonssonM Kubista
Oct 9, 1998·The Journal of Biological Chemistry·H SunN Maizels
Nov 7, 1998·The Journal of Biological Chemistry·M N WeitzmannK Usdin
Dec 24, 1998·Nucleic Acids Research·H HanM Salazar
Jan 12, 1999·Experimental Cell Research·N Claij, H te Riele
Apr 9, 1999·Biochemistry·V M Marathias, P H Bolton
Oct 26, 1999·Biochemical and Biophysical Research Communications·M KatahiraM Nagao
Apr 18, 2000·Human Molecular Genetics·C J Cummings, H Y Zoghbi
Jun 30, 2000·Molecular Genetics and Metabolism·O HandtR I Richards
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·A LewG C Kennedy
Feb 22, 2001·Science·J C VenterX Zhu
Mar 21, 2001·Human Molecular Genetics·P Peltomäki
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·C SchaffitzelA Plückthun
Sep 8, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·D C CrawfordS L Sherman
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·H SunN Maizels

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Citations

Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·David L AdelsonRobert C Edgar
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Feng WangZheng Tan
Jul 24, 2012·Journal of Bioinformatics and Computational Biology·Madhavi K GanapathirajuSeshan Ananthasubramanian
Aug 8, 2009·BMC Genomics·Nicolas SmargiassoAntoine Claessens
Nov 30, 2007·BMC Genomics·Chia-Ni LeeShu-Fen Weng
Jul 4, 2012·BMC Molecular Biology·Edward A EhratErik D Larson
Jul 31, 2010·The FEBS Journal·Yuliang Wu, Robert M Brosh
May 16, 2007·Biochemical and Biophysical Research Communications·Etsuko TanakaHitoshi Nakagama
Aug 28, 2010·The Biochemical Journal·Siew Ping HanRoss Smith
Jul 21, 2017·Frontiers in Plant Science·Vikas YadavPuja Yadav

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