Molecular Mechanisms Governing Embryonic Differentiation of Pituitary Somatotropes

Trends in Endocrinology and Metabolism : TEM
Buffy S Ellsworth, Caitlin E Stallings

Abstract

Pituitary somatotropes secrete growth hormone (GH), which is essential for normal growth and metabolism. Somatotrope defects result in GH deficiency (GHD), leading to short stature in childhood and increased cardiovascular morbidity and mortality in adulthood. Current hormone replacement therapies fail to recapitulate normal pulsatile GH secretion. Stem cell therapies could overcome this problem but are dependent on a thorough understanding of somatotrope differentiation. Although several transcription factors, signaling pathways, and hormones that regulate this process have been identified, the mechanisms of action are not well understood. The purpose of this review is to highlight the known players in somatotrope differentiation while emphasizing the need to better understand these pathways to serve patients with GHD.

Citations

Mar 8, 2019·Annals of Human Genetics·Yorran Hardman A MontenegroSimone Silva Dos Santos-Lopes
Aug 17, 2020·International Journal of Molecular Sciences·Bartłomiej BudnyKatarzyna Ziemnicka

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