PMID: 18720757Aug 30, 2008Paper

Molecular mechanisms involved in chemoresistance in paediatric acute lymphoblastic leukaemia

Srpski arhiv za celokupno lekarstvo
Tatjana Stankovic, Eliot Marston

Abstract

Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer. Despite cure rates approaching 80%, resistance to treatment and disease relapse remain a significant clinical problem. Identification of the genes and biological pathways responsible for chemoresistance is therefore crucial for the design of novel therapeutic approaches aiming to improve patient survival. Mutations in the membrane transporter P-glycoprotein genes, genetic variations in drug-metabolising enzymes and defects in apoptotic pathways are mechanisms of chemoresistance common to a wide spectrum of cancers and also play a role in paediatric ALL. In addition, several recent microarray studies have identified transcriptional profiles specifically associated with chemoresistance and pointed to a number of potentially novel therapeutic targets. These microarray studies have shown that genes discriminating between clinically responsive and resistant leukaemias tend to be involved in cellular processes such as regulation of cell cycle, proliferation, and DNA repair. Here we review the outcomes of these microarray studies and also present our own investigations into apoptotic resistance to DNA double strand breaks (DSBs) in paediatric ALL. We present str...Continue Reading

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Citations

Jan 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Majid SafaAhmad Kazemi
Jan 8, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rima Manafi ShabestariAhmad Kazemi
May 18, 2019·International Journal of Molecular Sciences·Minerva Mata-RochaJuan Manuel Mejía-Aranguré
Sep 4, 2015·The Journal of Pharmacology and Experimental Therapeutics·Cyril SobolewskiMarc Diederich
Jan 1, 2021·International Journal of Molecular Sciences·Miguel Olivas-AguirreOxana Dobrovinskaya

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