Molecular mechanisms involved in depotentiation and their relevance to schizophrenia.

Chonnam Medical Journal
Thomas M Sanderson

Abstract

Long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission are forms of synaptic plasticity that have been studied extensively and are thought to contribute to learning and memory. The reversal of LTP, known as depotentiation (DP) has received far less attention however, and its role in behavior is also far from clear. Recently, deficits in depotentiation have been observed in models of schizophrenia, suggesting that a greater understanding of this form of synaptic plasticity may help reveal the physiological alterations that underlie symptoms experienced by patients. This review therefore seeks to summarize the current state of knowledge on DP, and then put the deficits in DP in models of disease into this context.

References

Oct 30, 1990·Neuroscience Letters·A AraiG Lynch
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Lisman
Jan 1, 1994·Experimental Brain Research·Z I Bashir, G L Collingridge
Jan 8, 1993·Brain Research·J LarsonG Lynch
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ZhuoE R Kandel
Aug 13, 1999·Journal of Neurophysiology·S L Morgan, T J Teyler
Feb 8, 2002·Neuron·György Buzsáki
Jun 8, 2002·Annual Review of Neuroscience·David A Lewis, Pat Levitt
Jun 29, 2004·Trends in Neurosciences·Qiang Zhou, Mu-ming Poo
Sep 10, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter V MasseyZafar I Bashir
Jun 15, 2005·Neuron·Yinghua ZhuJ Julius Zhu
Jul 13, 2005·Trends in Genetics : TIG·M J OwenM C O'Donovan
Oct 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oh-Bin KwonAndres Buonanno
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tyson B BrustBrian A MacVicar
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Oh Bin KwonAndres Buonanno
Dec 5, 2008·Journal of Neurochemistry·Peter R MoultJenni Harvey
Jan 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hee Jung ChungLily Yeh Jan
Jan 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hee Jung ChungLily Yeh Jan
Sep 1, 2009·Behavioural Brain Research·Daniel J Lodge, Anthony A Grace
Oct 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Detlef VullhorstAndres Buonanno
Jun 19, 2010·Nature Reviews. Neuroscience·Graham L CollingridgeYu Tian Wang
Jul 29, 2011·Molecular Brain·Thomas M SandersonStephen M Fitzjohn
Jan 31, 2012·Neuron·Céline S NicolasGraham L Collingridge
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alon ShamirAndres Buonanno

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Citations

Mar 20, 2015·Journal of Neuroscience Research·Tomasz Wójtowicz, Jerzy W Mozrzymas
Jul 6, 2016·Scientific Reports·Seonghoo HuhByeong C Kim
Dec 10, 2019·Acta Neuropathologica Communications·Enrico FaldiniDetlef Balschun

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