PMID: 8589839Aug 1, 1995Paper

Molecular mechanisms involved in increased expression of a cytochrome P450 responsible for pyrethroid resistance in the housefly, Musca domestica

Insect Molecular Biology
T TomitaJ G Scott

Abstract

Cytochrome P450 Ipr is a developmentally regulated P450 responsible for monooxygenase-mediated pyrethroid resistance in the LPR strain of housefly. CYP6D1, the gene coding for P450 Ipr, has recently been sequenced. We investigated the molecular basis for CYP6D1-mediated pyrethroid resistance by comparison of mRNA levels, gene sequences, and gene copy number between LPR and pyrethroid susceptible strains of housefly. CYP6D1 mRNA levels were elevated in the LPR strain to a similar level as P450 Ipr protein, suggesting that over-expression of this important P450 in the resistant strain is probably due to increased transcription. Southern blots of susceptible and LPR strain DNA suggest that gene amplification is probably not involved in the increased expression of CYP6D1 protein. Five alleles of CYP6D1 were discovered and their possible role in resistance is discussed.

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Citations

Apr 29, 2009·Ecotoxicology·John M Brausch, Philip N Smith
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·J G ScottZ Wen
Nov 24, 2001·Insect Biochemistry and Molecular Biology·S Kasai, J G Scott
Jul 1, 1996·Insect Biochemistry and Molecular Biology·J G Scott
May 7, 1998·Insect Biochemistry and Molecular Biology·F F Smith, J G Scott
Oct 1, 1998·Insect Biochemistry and Molecular Biology·N Liu, J G Scott
Oct 8, 1999·Insect Biochemistry and Molecular Biology·J G Scott
Mar 20, 2004·European Journal of Biochemistry·Marcel AmichotJean-Baptiste Bergé
Feb 17, 1999·Annual Review of Entomology·E Zlotkin
Feb 17, 1999·Annual Review of Entomology·R Feyereisen
Dec 29, 1998·Emerging Infectious Diseases·W G Brogdon, J C McAllister
Nov 7, 2001·Pest Management Science·J G Scott, Z Wen
Jun 22, 2002·Journal of Economic Entomology·Jeffery K TomberlinJohn A Joyce
Jul 19, 2011·Pesticide Biochemistry and Physiology·George Guan-Hua Lin, Jeffrey G Scott
Jun 16, 2015·Insect Biochemistry and Molecular Biology·Selim TerhzazShireen-A Davies
May 23, 2007·Insect Biochemistry and Molecular Biology·Frank D RinkevichJeffrey G Scott
Jul 11, 2008·Archives of Insect Biochemistry and Physiology·Soamrutai BoonsuepsakulPornpimol Rongnoparut
Feb 11, 2011·Archives of Insect Biochemistry and Physiology·Panida DuangkaewPornpimol Rongnoparut
Dec 2, 2011·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Vatan TaşkınBelgin Göçmen Taşkin
Jun 18, 2011·Pest Management Science·Mette D K Markussen, Michael Kristensen
Nov 15, 2013·Pest Management Science·Dorte H HøjlandMichael Kristensen
Apr 27, 2012·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Felix David GuerreroJoão Ricardo Martins
Mar 17, 2001·Nature Reviews. Genetics·D Schneider
Jan 5, 2002·Journal of Personality and Social Psychology·R S Friedman, J Forster
Nov 19, 2005·Biological Reviews of the Cambridge Philosophical Society·Lloyd S PeckDavid K A Barnes
Aug 19, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mary BakhanashviliGalia Rahav
Apr 14, 2005·Journal of the American Mosquito Control Association·Prinyada RodpraditPornpimol Rongnoparut

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