Molecular mechanisms of anti-oxidant and anti-aging effects induced by convallatoxin in Caenorhabditis elegans

Free Radical Research
Jia XuLiping Wang

Abstract

Convallatoxin is widely used as a cardiac glycoside in acute and chronic congestive heart-failure and paroxysmal tachycardia, with many effects and underlying protective mechanisms on inflammation and cellular proliferation. However, convallatoxin has not been investigated in its antioxidant effects and lifespan extension in Caenorhabditis elegans. In this study, we found that convallatoxin (20 μM) could significantly prolong the lifespan of wild-type C. elegans up to 16.3% through daf-16, but not sir-2.1 signalling and increased thermotolerance and resistance to paraquat-induced oxidative stress. Convallatoxin also improved pharyngeal pumping, locomotion, reduced lipofuscin accumulation and reactive oxygen species levels in C. elegans, which were attributed to hormesis, free radical-scavenging effects in vivo, and up-regulation of stress resistance-related proteins, such as SOD-3 and HSP-16.1. Furthermore, aging-associated genes daf-16, sod-3, and ctl-2 also appeared to contribute to the stress-resistance effect of convallatoxin. In summary, this study demonstrates that convallatoxin can protect against heat and oxidative stress and extend the lifespan of C. elegans, pointing it as a potential novel drug for retarding the agin...Continue Reading

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Citations

Oct 27, 2017·Free Radical Research·Shachi Shuchi SmitaRakesh Pandey
Jul 12, 2018·The Journal of Pharmacy and Pharmacology·Yong Seong KimDong Seok Cha
Aug 2, 2018·Médecine sciences : M/S·Rachel LitkeChantal Fradin
Apr 30, 2020·Archives of Virology·Laurita BoffCláudia Maria Oliveira Simões
Apr 15, 2021·Parasite : Journal De La Société Française De Parasitologie·Camila S FreitasEduardo A F Coelho

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